This paper reflects on the interaction between religion and science in the Covid-19 discourses in Nigeria, drawing on a thematic analysis of Neo-Pentecostal sermons. If authors have mostly noted the complementary and dynamic relationship between science and religion in the context of the Covid-19 epidemics, this article shows how Nigerian Neo-Pentecostal sermons mostly contradicted scientific and State-sponsored information on the virus. Key themes that emerged from the analysis of sermons include: religious conceptions/interpretations of Covid-19 that negate or contradict science-based facts about Covid-19; contention of the reality of Covid-19 cases in Nigeria; emphasis on spiritual exemption; and the power of anointing for healing, as well as divergent views on adherence to safety measures. Building on Barbour's four models of interaction, the study identifies a tension or conflict rather than a complementary relationship between science and religion in the Neo-Pentecostal discourses on Covid-19in Nigeria. This represents a unique contribution to discussions on the relationship between religion and science, and an original insight into Covid-19 discourses in Nigeria.