DM1 Dynamin 2 KNOCKOUT MICE Muscle Cell model Transgenic mouse model BIOLOGIE MOLECULAIRE Oligodendrocyte Antisense oligonucleotide Cytoskeleton Fibrosis Glucocorticoids Cell culture model Trinucleotide Repeat Expansion Central nervous system CMS Brain Centronuclear myopathy ACETYLCHOLINESTERASE Myotonic Dystrophy Type 1 Glucocorticoid-receptor Duchenne muscular dystrophy Long read sequencing Dystrophin Brain dysfunction GABA MBNL Skeletal muscle PCR Transgenic mouse Exercise Acute coronary syndrome RNA biology GSK3␤ Heart CRISPR/Cas9 In vivo Acetylcholinesterase knockout mouse Expression Acetylcholinesterase deficiency Astrocytes Transcriptomics ARN Endurance training Trinucleotide repeat expansion Genotype phenotype correlation Alternative splicing Muscular dystrophy Gene Therapy Neuron Animals RNA interference Glutamate Mouse model Desmin Myostatin Oligodendrocytes Knockout Myotonic Dystrophy Dilated cardiomyopathy Antisense oligonucleotides Myotonic dystrophy Cardiac muscle Glial cells Cell penetrating peptide DMPK CONGENITAL MYATHENIC SYNDROME CTG repeats AAV Quantitative microdialysis Dystrophie Myotonique RNA splicing Diaphragm Myotonic dystrophy type 1 Dystrophie myotonique CTG repeat instability PacBio Intermediate filament Male Astrocyte Gene editing Myotonic Dystrophy type 1 CRISPRi Humans Hypoxia Myotonic dystrophy mouse models CTG repeat contractions Maximal force Motoneuron Mouse models Thérapie génique Mice Autophagy Gene therapy Heart failure Therapy Aging Exercice Myelin DMSXL mice