Copper-Catalyzed Preparation of gamma-Alkylidenebutenolides and Isocoumarins under Mild Palladium-Free Conditions - Aix-Marseille Université Access content directly
Journal Articles Advanced Synthesis and Catalysis Year : 2009

Copper-Catalyzed Preparation of gamma-Alkylidenebutenolides and Isocoumarins under Mild Palladium-Free Conditions

Abstract

A general and efficient copper(I)-catalyzed cross-coupling and heterocyclization reaction of terminal alkynes and b-iodo-a,b-unsaturated acid dérivatives has been developed under very mild conditions. This method provides easy access from good to excellent yields of a variety of 5-ylidenebutenolides and 3-substituted isocoumarins with excellent regioand stereoselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium-free.
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hal-00678956 , version 1 (14-03-2012)

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Samuel Inack-Ngi, Raphaël Rahmani, Laurent Commeiras, Gaëlle Chouraqui, Jérôme Thibonnet, et al.. Copper-Catalyzed Preparation of gamma-Alkylidenebutenolides and Isocoumarins under Mild Palladium-Free Conditions. Advanced Synthesis and Catalysis, 2009, 351, pp.779 - 788. ⟨10.1002/adsc.200800757⟩. ⟨hal-00678956⟩

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