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Journal Articles Chemistry - A European Journal Year : 2012

Catalyst- and Halogen-Free Regioselective Friedel-Crafts alpha-Ketoacylations

Kishor Mohanan
  • Function : Author
Marc Presset
  • Function : Author
Damien Mailhol
  • Function : Author
Yoann Coquerel
Jean Rodriguez
  • Function : Author
  • PersonId : 921781
  • IdRef : 260692638

Abstract

Highly regio- selective and efficient catalyst- and halogen-free Friedel-Crafts alpha-ketoacy- lation reactions leading to heterocycles functionalized with a very versatile 1,3- diketone moiety are described. The reactions rely on microwave-assisted domino Wolff rearrangement/Friedel- Crafts sequences from 2-diazo-1,3- diketones via transient, highly reactive alpha-keto ketene intermediates.

Dates and versions

hal-00736640 , version 1 (28-09-2012)

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Kishor Mohanan, Marc Presset, Damien Mailhol, Yoann Coquerel, Jean Rodriguez. Catalyst- and Halogen-Free Regioselective Friedel-Crafts alpha-Ketoacylations. Chemistry - A European Journal, 2012, 18, pp.9217-9220. ⟨10.1002/chem.201201027⟩. ⟨hal-00736640⟩
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