Organocatalytic multicomponent synthesis of enantioenriched polycyclic 1,2,3,4-tetrahydro-pyridines: key substrate selection enabling regio-and stereoselectivities †
Abstract
We have developed the first multicomponent synthesis of enantioenriched polycyclic 1,2,3,4-tetrahydropyridines bearing three contiguous stereogenic centers under iminium activation. The key to the success of this reaction was the use of polyfunctional substrates including 2-aminophenols and scarcely used β-ketoamides triggering a thermodynamically controlled regio- and diastereoselective sequence.
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