Antinuclear Antibodies in Patients with Psoriatic Arthritis Treated or Not with Biologics - Aix-Marseille Université Access content directly
Journal Articles PLoS ONE Year : 2015

Antinuclear Antibodies in Patients with Psoriatic Arthritis Treated or Not with Biologics

Abstract

Background:With the emergence of biotherapies, accurate diagnosis in early arthritis is needed. At this time, there is no biological marker of psoriatic arthritis. Objective:To test whether antinuclear antibodies (ANA) can be used as a diagnostic tool in psoriatic arthritis (PsA), we evaluated the prevalence of ANA in biologic-naïve PsA patients and in healthy blood donors. Methods:232 patients from the Rheumatology department, St Marguerite's Hospital, Marseilles, who fulfilled the CASPAR criteria for PsA, underwent clinical and laboratory investigations. Antinuclear antibodies (ANA), anti-extractable nuclear antigen antibodies (ENA), rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) were assayed. Ninety-one healthy blood donors were also tested. Results:Detection of ANA by indirect immunofluorescence was significantly more frequent in sera from PsA patients than those from controls at serum dilution of 1:100 (57% compared with 40%, Odds Ratio (OR) 1.98 (1.2-3.4) p<0.02) and 1:160 (52% compared with 24%, OR 3,7 (1.9-7.2) p<0.001). No patients had lupus specific autoantibodies, 15 % had RF (34/232), and 1.7 % had ACPA (4/232). Conclusions:Detection of ANA was more frequent in sera from PsA patients than in those from healthy controls. This suggests that ANA could be a diagnosis orientation tool in PsA. Nevertheless, the specificity of these antibodies still remains to be investigated.
Fichier principal
Vignette du fichier
fetchObject.pdf (186.03 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive
Loading...

Dates and versions

hal-01199476 , version 1 (15-09-2015)

Identifiers

Cite

Florent Silvy, Daniel Bertin, Nathalie Bardin, Isabelle Auger, Marie-Caroline Guzian, et al.. Antinuclear Antibodies in Patients with Psoriatic Arthritis Treated or Not with Biologics. PLoS ONE, 2015, pp.1-8. ⟨10.1371/journal.pone.0134218⟩. ⟨hal-01199476⟩

Collections

CNRS UNIV-AMU
115 View
159 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More