%0 Journal Article %T First Reported Chikungunya Fever Outbreak in the Republic of Congo, 2011 %+ Emergence des Pathologies Virales (EPV) %+ Laboratoire National de Santé Publique %+ Centre National de Transfusion Sanguine %+ French National Reference Centre for Arboviruses %+ Laboratory of Virology %A Moyen, Nanikaly %A Thiberville, Simon-Djamel %A Pastorino, Boris %A Nougairede, Antoine %A Thirion, Laurence %A Mombouli, Jean-Vivien %A Dimi, Yannick %A Leparc-Goffart, Isabelle %A Capobianchi, Maria Rosaria %A Lepfoundzou, Amelia Dzia %A de Lamballerie, Xavier %< avec comité de lecture %@ 1932-6203 %J PLoS ONE %I Public Library of Science %V 9 %N e115938 %8 2014-12-26 %D 2014 %R 10.1371/journal.pone.0115938 %K REUNION-ISLAND %K INDIAN-OCEAN %K PERSISTENT ARTHRALGIA %K MAXIMUM-LIKELIHOOD %K VIRUS-INFECTION %K EPIDEMIC %K COHORT %K GABON %Z Life Sciences [q-bio]/Microbiology and Parasitology/VirologyJournal articles %X Background: Chikungunya is an Aedes-borne disease characterised by febrile arthralgia and responsible for massive outbreaks. We present a prospective clinical cohort study and a retrospective serological study relating to a CHIK outbreak, in the Republic of Congo in 2011. Methodology and Findings: We analysed 317 suspected cases, of which 308 (97.2%) lived in the city of Brazzaville (66.6% in the South area). Amongst them, 37 (11.7%) were CHIKV+ve patients (i.e., biologically confirmed by a real-time RT-PCR assay), of whom 36 (97.3%) had fever, 22 (66.7%) myalgia and 32 (86.5%) arthralgia. All tested negative for dengue. The distribution of incident cases within Brazzaville districts was compared with CHIKV seroprevalence before the outbreak (34.4% in 517 blood donors), providing evidence for previous circulation of CHIKV. We applied a CHIK clinical score to 126 patients recruited within the two first day of illness (including 28 CHIKV+ves (22.2%)) with sensitivity (78.6%) and specificity (72.4%) values comparing with those of the referent study in Reunion Island. The negative predictive value was high (92%), but the positive predictive value (45%) indicate poor potential contribution to medical practice to identify CHIKV+ve patients in low prevalence outbreaks. However, the score allowed a slightly more accurate follow-up of the evolution of the outbreak than the criterion "fever+arthralgia". The complete sequencing of a Congolase isolate (Brazza_MRS1) demonstrated belonging to the East/Central/South African lineage %G English %2 https://amu.hal.science/hal-01239146/document %2 https://amu.hal.science/hal-01239146/file/fetchObject.pdf %L hal-01239146 %U https://amu.hal.science/hal-01239146 %~ IRD %~ UNIV-AMU %~ TEST3-HALCNRS