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              <p>Background Novel treatments against for tinea capitis are needed, and the natural aminosterol squal-amine is a potential topical antidermatophyte drug candidate. Objectives This phase II randomized double-blind placebo-controlled clinical trial aimed at testing the efficacy and safety of a three-week squalamine ointment regimen for the treatment of tinea capitis. Patients Males aged 6–15 years presenting with tinea capitis were treated with either topical squal-amine ointment or placebo for 3 weeks. The primary endpoint was complete clinical cure. The secondary endpoints were the occurrence of local and/or sys-temic adverse events, mycological cure, and partial clinical response. Prospective follow-up of clinical adverse events was performed daily. Results Five patients were treated with 1 % squal-amine ointment and 15 with placebo. No complete cure was observed. No clinical or biological adverse event was recorded. A significantly (p = 0.03) better hair-growth score, indicating a partial clinical improvement of the tinea capitis lesion, was observed in the patients treated with squalamine compared to those treated with placebo. Conclusion This three-week squalamine ointment regimen was well tolerated and showed an encouraging partial clinical activity for the treatment of tinea capitis. Further studies are needed to evaluate the efficacy of topical squalamine alone against tinea corporis or in combination with a systemic antider-matophyte drug against tinea capitis.</p>
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          <orgName>Malaria Research and Training Center [Bamako, Mali]</orgName>
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            <address>
              <country key="ML"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-302584" type="direct"/>
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        </org>
        <org type="regrouplaboratory" xml:id="struct-34312" status="VALID">
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          <orgName>International Institute of Tropical Agriculture [Nigeria]</orgName>
          <orgName type="acronym">IITA</orgName>
          <desc>
            <address>
              <addrLine>IITA HeadquartersOyo State, Nigeria</addrLine>
              <country key="NG"/>
            </address>
            <ref type="url">https://www.iita.org/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300980" type="direct"/>
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        </org>
        <org type="regroupinstitution" xml:id="struct-300980" status="VALID">
          <idno type="ROR">https://ror.org/04c4bm785</idno>
          <orgName>Consultative Group on International Agricultural Research [CGIAR]</orgName>
          <orgName type="acronym">CGIAR</orgName>
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            <address>
              <addrLine>CGIAR System Management Office1000, Avenue AgropolisF-34394 Montpellier cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cgiar.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300073" status="VALID">
          <idno type="ROR">https://ror.org/002cp4060</idno>
          <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
          <orgName type="acronym">APHM</orgName>
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            <address>
              <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300092" status="VALID">
          <orgName>Service de Santé des Armées</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.defense.gouv.fr/sante</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302584" status="VALID">
          <idno type="ROR">https://ror.org/023rbaw78</idno>
          <orgName>Université des Sciences, des Techniques et des Technologies de Bamako</orgName>
          <orgName type="acronym">USTTB</orgName>
          <desc>
            <address>
              <addrLine>Bamako</addrLine>
              <country key="ML"/>
            </address>
            <ref type="url">http://www.usttb.edu.ml/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>