D. Ford, D. F. Easton, D. T. Bishop, S. A. Narod, D. E. Goldgar et al., Risks of cancer in BRCA1-mutation carriers, The Lancet, vol.343, issue.8899, pp.692-695, 1994.
DOI : 10.1016/S0140-6736(94)91578-4

S. A. Smith, D. F. Easton, D. G. Evans, and B. A. Ponder, Allele losses in the region 17q12???21 in familial breast and ovarian cancer involve the wild???type chromosome, Nature Genetics, vol.18, issue.2, pp.128-131, 1992.
DOI : 10.1038/342177a0

S. L. Neuhausen, M. , and C. J. , Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds, Cancer Res, vol.54, pp.6069-6072, 1994.

M. E. Thompson, R. A. Jensen, P. S. Obermiller, D. L. Page, and J. T. Holt, Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression, Nature Genetics, vol.8, issue.4, pp.444-450, 1995.
DOI : 10.1128/MCB.8.2.963

F. Magdinier, S. Ribieras, G. M. Lenoir, L. Frappart, D. et al., Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region, Oncogene, vol.17, issue.24, pp.3169-3176, 1998.
DOI : 10.1038/sj.onc.1202248

C. A. Wilson, L. Ramos, M. R. Villasenor, K. H. Anders, M. F. Press et al., Localization of human BRCA1 and its loss in high grade, non inherited breast carcinomas, Nat. Genet, vol.21, pp.236-240, 1999.

R. Hakem, J. L. De-la-pompa, C. Sirard, R. Mo, M. Woo et al., The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse, Cell, vol.85, issue.7, pp.1009-1023, 1996.
DOI : 10.1016/S0092-8674(00)81302-1

S. T. Marquis, J. V. Rajan, A. Wynshaw-boris, J. Xu, G. Y. Yin et al., The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues, Nature Genetics, vol.18, issue.1, pp.17-26, 1995.
DOI : 10.1038/ng1192-240

T. F. Lane, C. Deng, A. Elson, M. S. Lyu, C. A. Kozak et al., Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice., Genes & Development, vol.9, issue.21, pp.2712-2722, 1995.
DOI : 10.1101/gad.9.21.2712

P. E. Blackshear, S. M. Goldsworthy, J. F. Foley, K. A. Mcallister, L. M. Bennett et al., Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice, Oncogene, vol.16, issue.1, pp.61-68, 1998.
DOI : 10.1038/sj.onc.1201506

X. Xu, K. U. Wagner, L. D. Larson, Z. Weaver, C. Li et al., Conditional mutant of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation, Nat. Genet, vol.22, pp.37-43, 1999.

F. Magdinier, D. Venezia, N. Lenoir, G. M. Frappart, L. et al., BRCA1 expression during prenatal development of the human mammary gland, Oncogene, vol.18, issue.27, pp.4039-4043, 1999.
DOI : 10.1007/978-1-4899-5043-7_2

URL : https://hal.archives-ouvertes.fr/hal-01663803

N. Xu, C. F. Brown, M. A. Nicolai, H. Chambers, J. A. Griffiths et al., Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene, Human Molecular Genetics, vol.6, issue.7, pp.1057-1062, 1997.
DOI : 10.1093/hmg/6.7.1057

C. F. Xu, J. A. Chambers, and E. Solomon, Complex regulation of the BRCA1 gene, J. Biol. Chem, vol.34, pp.20994-20997, 1997.

S. Thakur, C. , and C. M. , Positive Regulation of the BRCA1 Promoter, Journal of Biological Chemistry, vol.269, issue.13, pp.8837-8843, 1999.
DOI : 10.1073/pnas.87.7.2705

A. Dobrovic and D. Simpfendorfer, Methylation of the BRCA1 gene in sporadic breast cancer, Cancer Res, vol.57, pp.3347-3350, 1997.

J. C. Rice, K. S. Massey-brown, and B. W. Futscher, Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells, Oncogene, vol.17, issue.14, pp.1807-1812, 1998.
DOI : 10.1038/sj.onc.1202086

A. Catteau, W. H. Harris, C. F. Xu, and E. Solomon, Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics, Oncogene, vol.18, issue.11, pp.1957-1965, 1999.
DOI : 10.1002/ijc.2910540405

J. Boyes and A. Bird, Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein, 1992.

S. B. Baylin, J. G. Herman, J. R. Graff, P. M. Vertino, and J. P. Issa, Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia, Adv. Cancer Res, pp.141-196, 1997.
DOI : 10.1016/S0065-230X(08)60702-2

P. A. Jones, L. , and P. W. , Cancer epigenetics comes of age, Nature Genetics, vol.21, issue.2, pp.163-167, 1999.
DOI : 10.1038/5947

P. H. Tate and A. P. Bird, Effects of DNA methylation on DNA-binding proteins and gene expression, Current Opinion in Genetics & Development, vol.3, issue.2, pp.226-231, 1993.
DOI : 10.1016/0959-437X(93)90027-M

M. Constância, B. Pickard, G. Kelsey, R. , and W. , Imprinting Mechanisms, Genome Research, vol.13, issue.9, pp.881-900, 1998.
DOI : 10.1128/MCB.13.11.6810

X. Nan, F. J. Campoy, and A. Bird, MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin, Cell, vol.88, issue.4, pp.471-481, 1997.
DOI : 10.1016/S0092-8674(00)81887-5

J. D. Lewis, R. R. Meehan, W. J. Henzel, I. Maurer-fogy, P. Jeppesen et al., Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA, Cell, vol.69, issue.6, pp.905-914, 1992.
DOI : 10.1016/0092-8674(92)90610-O

X. Nan, P. Tate, E. Li, and A. Bird, DNA methylation specifies chromosomal localization of MeCP2., Molecular and Cellular Biology, vol.16, issue.1, pp.414-421, 1996.
DOI : 10.1128/MCB.16.1.414

X. Nan, H. H. Ng, C. A. Johnson, C. D. Laherty, B. M. Turner et al., Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex, Nature, vol.314, issue.6683, pp.386-389, 1998.
DOI : 10.1042/bj3140631

P. L. Jones, G. J. Veenstra, P. A. Wade, D. Vermaak, S. U. Kass et al., Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription, Nature Genetics, vol.267, issue.2, pp.187-191, 1998.
DOI : 10.1006/jmbi.1997.0899

E. E. Cameron, K. E. Bachman, S. My?hänen, J. G. Herman, and S. B. Baylin, Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer, Nature Genetics, vol.311, issue.1, pp.103-107
DOI : 10.1042/bj3110549

J. Sambrook, E. F. Fritsch, and T. Maniatis, Molecular cloning: A Laboratory Manual, 1989.

P. Chomczynski and N. Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Analytical Biochemistry, vol.162, issue.1, pp.156-159, 1987.
DOI : 10.1016/0003-2697(87)90021-2

S. Ribieras, F. Magdinier, D. Leclerc, G. M. Lenoir, L. Frappart et al., Abundance ofBRCA1 transcripts in human cancer and lymphoblastoid cell lines carryingBRCA1 germ-line alterations, International Journal of Cancer, vol.14, issue.5, pp.715-718, 1997.
DOI : 10.1038/sj.onc.1200924

URL : http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0215(19971127)73:5<715::AID-IJC17>3.0.CO;2-4/pdf

T. M. Smith, M. K. Lee, C. I. Szabo, N. Jerome, M. Mceuen et al., Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1., Genome Research, vol.6, issue.11, pp.1029-1049, 1996.
DOI : 10.1101/gr.6.11.1029

V. Martin, S. Ribieras, X. W. Song-wang, Y. Lasne, L. Frappart et al., Involvement of DNA methylation in the control of the expression of an estrogen-induced breast-cancer-associated protein (pS2) in human breast cancers, Journal of Cellular Biochemistry, vol.5, issue.1, pp.95-106, 1997.
DOI : 10.1210/mend-5-11-1613

F. Antequera, J. Boyes, and A. Bird, High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines, Cell, vol.62, issue.3, pp.503-514, 1990.
DOI : 10.1016/0092-8674(90)90015-7

M. Toyota, N. Ahuja, M. Ohe-toyota, J. G. Herman, S. B. Baylin et al., CpG island methylator phenotype in colorectal cancer, Proc. Natl. Acad. Sci. USA, pp.8681-8686, 1999.
DOI : 10.1038/sj.onc.1201831

T. C. Suen and P. E. Goss, Is Dependent on the Formation of a Specific Protein-DNA Complex on the Minimal BRCA1 Bi-directional Promoter, Journal of Biological Chemistry, vol.57, issue.44, pp.31297-31304, 1999.
DOI : 10.1006/bbrc.1998.8379

X. Nan, F. J. Campoy, and A. Bird, MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin, Cell, vol.88, issue.4, pp.471-481, 1997.
DOI : 10.1016/S0092-8674(00)81887-5

J. A. Chambers and E. Solomon, Isolation of the MurineNbr1Gene Adjacent to the MurineBrca1Gene, Genomics, vol.38, issue.3, pp.305-313, 1996.
DOI : 10.1006/geno.1996.0633

P. A. Wade, A. Gegonne, P. L. Jones, E. Ballestar, F. Aubry et al., Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation, Nat. Genet, vol.23, pp.62-66, 1999.

R. R. Meehan, J. D. Lewis, and A. Bird, Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA, Nucleic Acids Research, vol.20, issue.19, pp.5085-5092, 1992.
DOI : 10.1093/nar/20.19.5085

Y. Toh, S. D. Pencil, and G. L. Nicolson, A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastic mammary adenocarcinoma cell lines, J. Biol. Chem, vol.269, pp.22958-22963, 1994.