TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion

Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of malignant tissues and cancer cell lines and was shown to be a mitogenic factor capable of stimulating growth of several cancer cell types. In addition, AM is a survival factor for certain cancer cells. Some data suggest that AM might be involved in the progression cancer metastasis via angiogenesis and cell migration and invasion control. The Transient Receptor Potential channel TRPV2 is known to promote in prostate cancer cell migration and invasive phenotype and is correlated with the stage and grade of bladder cancer. In this work we show that AM induces prostate and urothelial cancer cell migration and invasion through TRPV2 translocation to plasma membrane and the subsequent increase in resting calcium level.

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Cancer

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journal.pone.0064885.pdf (718.29 Ko)

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Soumis le : mardi 13 février 2018-12:35:58

Dernière modification le : mercredi 23 novembre 2022-15:42:08

Archivage à long terme le : dimanche 6 mai 2018-04:53:08

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hal-01708095 , version 1 (13-02-2018)

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HAL Id : hal-01708095 , version 1
DOI : 10.1371/journal.pone.0064885

Citer

Agathe Oulidi, Alexandre Bokhobza, Dimitra Gkika, Fabien Vanden Abeele, V'Yacheslav Lehen'Kyi, et al.. TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion. PLoS ONE, 2013, 8 (5), pp.e64885. ⟨10.1371/journal.pone.0064885⟩. ⟨hal-01708095⟩

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