Natural killer cell immunotherapies against cancer: checkpoint inhibitors and more - Aix-Marseille Université Access content directly
Journal Articles Seminars in Immunology Year : 2017

Natural killer cell immunotherapies against cancer: checkpoint inhibitors and more

Abstract

After many years of research, recent advances have shed new light on the role of the immune system in advanced-stage cancer. Various types of immune cells may be useful for therapeutic purposes, along with chemical molecules and engineered monoclonal antibodies. The immune effectors suitable for manipulation for adoptive transfer or drug targeting in vivo include natural killer (NK) cells. These cells are of particular interest because they are tightly regulated by an array of inhibitory and activating receptors, enabling them to kill tumor cells while sparing normal cells. New therapeutic antibodies blocking the interactions of inhibitory receptors (immune checkpoint inhibitors, ICI) with their ligands have been developed and can potentiate NK cell functions in vivo.

Domains

Immunology
No file

Dates and versions

hal-01764667 , version 1 (12-04-2018)

Identifiers

Cite

Laura Chiossone, Margaux Vienne, Yann M. Kerdiles, Eric Vivier. Natural killer cell immunotherapies against cancer: checkpoint inhibitors and more. Seminars in Immunology, 2017, 31 (SI), pp.55-63. ⟨10.1016/j.smim.2017.08.003⟩. ⟨hal-01764667⟩
30 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More