Whipple Disease: Intestinal Infiltrating Cells Exhibit a Transcriptional Pattern of M2/Alternatively Activated Macrophages - Aix-Marseille Université Access content directly
Journal Articles Journal of Infectious Diseases Year : 2005

Whipple Disease: Intestinal Infiltrating Cells Exhibit a Transcriptional Pattern of M2/Alternatively Activated Macrophages

Abstract

Whipple disease (WD) is a rare systemic disease caused by Tropheryma whipplei and is characterized by the presence of foamy macrophages with periodic acid-Schiff-positive inclusions in tissues such as lamina propria. For the first time, we report the gene-expression profile of macrophages in intestinal lesions from a patient with WD. Microarray and real-time polymerase chain reaction revealed that genes encoding CCL18, cathepsins, scavenger receptor, interleukin-10, and lipid metabolites were up-regulated in intestinal lesions. This transcriptional pattern corresponds to that of M2/alternatively activated macrophages. Our results suggest that the T helper 2 response in the intestinal environment may account for the pathophysiological properties of WD.

Dates and versions

hal-02025872 , version 1 (19-02-2019)

Identifiers

Cite

Benoit Desnues, Hubert Lepidi, Didier Raoult, Jean-Louis Mege. Whipple Disease: Intestinal Infiltrating Cells Exhibit a Transcriptional Pattern of M2/Alternatively Activated Macrophages. Journal of Infectious Diseases, 2005, 192 (9), pp.1642-1646. ⟨10.1086/491745⟩. ⟨hal-02025872⟩

Collections

CNRS UNIV-AMU
30 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More