Respiratory sympathetic modulation is augmented in chronic kidney disease - Aix-Marseille Université Access content directly
Journal Articles Respiratory Physiology & Neurobiology Year : 2019

Respiratory sympathetic modulation is augmented in chronic kidney disease

Abstract

Respiratory modulation of sympathetic nerve activity (respSNA) was studied in a hypertensive rodent model of chronic kidney disease (CKD) using Lewis Polycystic Kidney (LPK) rats and Lewis controls. In adult animals under in vivo anaesthetised conditions (n=8-10/strain), respiratory modulation of splanchnic and renal nerve activity was compared under control conditions, and during peripheral (hypoxia), and central, chemoreceptor (hypercapnia) challenge. RespSNA was increased in the LPK vs. Lewis (area under curve (AUC) splanchnic and renal: 8.7±1.1 vs. 3.5±0.5 and 10.6±1.1 vs. 7.1±0.2 µV.s, respectively, P<0.05). Hypoxia and hypercapnia increased respSNA in both strains but the magnitude of the response was greater in LPK, particularly in response to hypoxia. In juvenile animals studied using a working heart brainstem preparation (n=7-10/strain), increased respSNA was evident in the LPK (thoracic SNA, AUC: 0.86±0.1 vs. 0.42±0.1 µV.s, P<0.05), and activation of peripheral chemoreceptors (NaCN) again drove a larger increase in respSNA in the LPK with no difference in the response to hypercapnia. Amplified respSNA occurs in CKD and may contribute to the development of hypertension.
Fichier principal
Vignette du fichier
2019 - Respiratory sympathetic modulation is augmented in chronic kidney disease - Saha M et al - Resp Physiol Neurobiol.pdf (1.92 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-02088225 , version 1 (02-04-2019)

Identifiers

Cite

Manash Saha, Clément Menuet, Qi-Jian Sun, Peter G.R. Burke, Cara M. Hildreth, et al.. Respiratory sympathetic modulation is augmented in chronic kidney disease. Respiratory Physiology & Neurobiology, In press. ⟨hal-02088225⟩
72 View
82 Download

Altmetric

Share

Gmail Facebook X LinkedIn More