A pH-driven ring translocation switch against cancer cells - Aix-Marseille Université Access content directly
Journal Articles Chemical Communications Year : 2018

A pH-driven ring translocation switch against cancer cells

Abstract

A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 10(2) cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.
Fichier principal
Vignette du fichier
A pH driven ring translocation switch.pdf (471.35 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-02091869 , version 1 (15-02-2022)

Identifiers

Cite

Qian Cheng, Hang Yin, Roselyne Rosas, Didier Gigmes, Olivier Ouari, et al.. A pH-driven ring translocation switch against cancer cells. Chemical Communications, 2018, 54 (98), pp.13825--13828. ⟨10.1039/c8cc08681h⟩. ⟨hal-02091869⟩
50 View
30 Download

Altmetric

Share

Gmail Facebook X LinkedIn More