Stromal Expression of MARCKS Protein in Ovarian Carcinomas Has Unfavorable Prognostic Value - Aix-Marseille Université Access content directly
Journal Articles International Journal of Molecular Sciences Year : 2018

Stromal Expression of MARCKS Protein in Ovarian Carcinomas Has Unfavorable Prognostic Value

Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Identification of new therapeutic targets is crucial. MARCKS, myristoylated alanine-rich C-kinase substrate, has been implicated in aggressiveness of several cancers and MARCKS inhibitors are in development. Using immunohistochemistry (IHC), we retrospectively assessed MARCKS expression in epithelial and stromal cells of 118 pre-chemotherapy EOC samples and 40 normal ovarian samples from patients treated at Salah Azaiez Institute. We compared MARCKS expression in normal versus cancer samples, and searched for correlations with clinicopathological features, including overall survival (OS). Seventy-five percent of normal samples showed positive epithelial MARCKS staining versus 50% of tumor samples (p = 6.02 x 10(-3)). By contrast, stromal MARCKS expression was more frequent in tumor samples (77%) than in normal samples (22%; p = 1.41 x 10(-9)). There was no correlation between epithelial and stromal IHC MARCKS statutes and prognostic clinicopathological features. Stromal MARCKS expression was correlated with shorter poor OS in uni- and multivariate analyses. Stromal MARCKS overexpression in tumors might contribute to cancer-associated fibroblasts activation and to the poor prognosis of EOC, suggesting a potential therapeutic interest of MARCKS inhibition for targeting the cooperative tumor stroma.
Fichier principal
Vignette du fichier
ijms-19-00041.pdf (753.72 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-02143620 , version 1 (21-01-2020)

Licence

Attribution

Identifiers

Cite

Raoudha Doghri, Maroua Manai, Pascal Finetti, Maha Driss, Emilie Agavnian, et al.. Stromal Expression of MARCKS Protein in Ovarian Carcinomas Has Unfavorable Prognostic Value. International Journal of Molecular Sciences, 2018, 19 (1), ⟨10.3390/ijms19010041⟩. ⟨hal-02143620⟩

Collections

CNRS UNIV-AMU CRCM
45 View
61 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More