Electroencephalogram Modifications Associated With Atypical Strict Antipsychotic Monotherapies - Aix-Marseille Université Access content directly
Journal Articles Journal of clinical psychopharmacology Year : 2018

Electroencephalogram Modifications Associated With Atypical Strict Antipsychotic Monotherapies


Background Antipsychotics produce electroencephalogram (EEG) modifications and increase the risk of epileptic seizure. These modifications remain sparsely studied specifically for atypical antipsychotics. In this context, our study focuses on EEG modifications associated with atypical strict antipsychotic monotherapies. Methods Electroencephalogram recordings of 84 psychiatric patients treated with atypical antipsychotics in strict monotherapy (clozapine, n = 22; aripiprazole, n = 22; olanzapine, n = 17; risperidone, n = 9; quetiapine, n = 8; risperidone long-acting injection, n = 4; and paliperidone long-acting injection, n = 2) were analyzed. The modifications were ranked according to both slowing and excitability scores. Results Electroencephalogram modifications (in 51 subjects, 60.71%) were graded according to 4 stages combining general slowing and sharp slow waves and/or epileptiform activities. The presence of sharp or epileptiform activities was significantly greater for clozapine (90.9%) compared with other second-generation antipsychotics (aripiprazole, 50%; olanzapine, 58.8%; quetiapine, 37.5%; risperidone, 44.4%). Age, duration of disease progression, and diagnosis were not associated as risk factors. Electroencephalogram modifications were associated with lower doses for treatment with quetiapine but not for specific antipsychotics. Electroencephalogram modifications and severe excitability were associated with higher chlorpromazine equivalent doses. Conclusions Atypical antipsychotics (clozapine, aripiprazole, quetiapine, olanzapine, and risperidone) induce EEG modifications, and these are significantly greater for clozapine and appear dependent on chlorpromazine equivalent dose. No encephalopathy was observed in these antipsychotic monotherapies, whatever dose.
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hal-02146856 , version 1 (04-06-2019)



Manuel Dias Alves, Jean Arthur Micoulaud-Franchi, Nicolas Simon, Jean Vion-Dury. Electroencephalogram Modifications Associated With Atypical Strict Antipsychotic Monotherapies. Journal of clinical psychopharmacology, 2018, 38 (6), pp.555-562. ⟨10.1097/JCP.0000000000000953⟩. ⟨hal-02146856⟩
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