Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy - Aix-Marseille Université Access content directly
Journal Articles Clinical and Experimental Allergy Year : 2019

Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy

1 Laboratoire Synlab Provence
2 CHU Saint-Antoine [AP-HP]
3 UMRS893 - Centre de Recherche Saint-Antoine
4 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
5 MEPHI - Microbes évolution phylogénie et infections
6 Thermo Fisher Scientific (Bremen) GmbH
7 Hôpital Saint-Joseph [Marseille]
8 Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM]
9 Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM]
10 CHIAP - Centre Hospitalier d'Aix en Provence [Aix-en-Provence]
11 Service d'immunologie et d'immunogénétique [Bordeaux]
12 Institut Fédératif de Biologie (IFB)
13 CHU - Hôpital Archet 2 [Nice]
14 Service d'immunologie [Centre Hospitalier Lyon Sud - HCL]
15 Département pneumologie et addictologie [Montpellier]
16 UM - Université de Montpellier
17 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
18 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
19 CHU Bordeaux
20 Hôpital Pellegrin
21 Centre Médical de Mérignac
22 Centre Médical de Cenon
23 CHU - Hôpital Pasteur [Nice]
24 CHU-Lenval - Hôpitaux Pédiatriques de Nice Lenval
25 APHM - Assistance Publique - Hôpitaux de Marseille
26 Espace Médical Castellane
27 TIMONE - Hôpital de la Timone [CHU - APHM]
28 Centre Hospitalier de Carpentras
29 Centre Hospitalier de Martigues
30 Centre hospitalier de Bormes-les-Mimosas
31 Centre Hospitalier Saint Jean de Perpignan
32 Centre Hospitalier de Solliès-Pont
33 Epidémiologie, Systèmes d'Information, Modélisation
Alain Poisson
  • Function : Author
  • PersonId : 1276497
  • IdRef : 070418152
Pol-André Apoil
  • Function : Author
  • PersonId : 1049110
Stéphane Guez
  • Function : Author
Denis Charpin
  • Function : Author
  • PersonId : 930345

Abstract

BACKGROUND: Peach is a common elicitor of food allergic reactions. Peach-induced immediate reactions may occur as benign pollen-food syndromes, usually due to birch pollen-related PR-10 cross-reactivity in temperate climates, and as potentially severe primary food allergies, predominantly related to nsLTP Pru p 3 in Mediterranean regions. The newly described peach allergen Pru p 7 has gained recent attention as a potential peach allergy severity marker. Sensitization to Pru p 7 and its allergenic homologues of the gibberellin-regulated protein family occurs in areas with high Cupressaceae tree pollen exposure. OBJECTIVE: We sought to investigate the distribution, clinical characteristics and molecular associations of Pru p 7 sensitization among subjects with suspected peach allergy in different regions of France. METHODS: Subjects with suspected peach allergy (n = 316) were included. Diagnostic work-up was performed according to current guidelines, including open food challenge when required. IgE antibody measurements and competition experiments were performed using the ImmunoCAP assay platform. RESULTS: Sensitization to Pru p 7 was present in 171 (54%) of all subjects in the study and in 123 of 198 (62%) diagnosed as peach allergic, more than half of whom were sensitized to no other peach allergen. Frequency and magnitude of Pru p 7 sensitization were associated with the presence of peach allergy, the clinical severity of peach-induced allergic reactions and the level of cypress pollen exposure. Cypress pollen extract completely outcompeted IgE binding to Pru p 7. Pru p 7 was extremely potent in basophil activation tests. CONCLUSION AND CLINICAL RELEVANCE: A subtype of Cupressaceae pollinosis, characterized by Pru p 7 sensitization, can be an underlying cause of severe peach allergy.
Fichier principal
Vignette du fichier
Klingebiel et al. - Pru p 7 sensitisation is a predominant cause of se.pdf (556.03 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-02202464 , version 1 (14-10-2019)

Identifiers

Cite

Caroline Klingebiel, Yannick Chantran, Rihane Arif‐lusson, Angelica Ehrenberg, Jonas Östling, et al.. Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy. Clinical and Experimental Allergy, 2019, 49 (4), pp.526-536. ⟨10.1111/cea.13345⟩. ⟨hal-02202464⟩
498 View
705 Download

Altmetric

Share

Gmail Facebook X LinkedIn More