Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors - Aix-Marseille Université Access content directly
Journal Articles Biological Psychiatry Year : 2019

Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors

Abstract

Cannabis usage is increasing with its widespread legalization. Cannabis use by mothers during lactation transfers active cannabinoids to the developing offspring during this critical period and alters postnatal neurodevelopment. A key neurodevelopmental landmark is the excitatory to inhibitory gamma-aminobutyric acid (GABA) switch caused by reciprocal changes in expression ratios of the K+/Cl− transporters potassium-chloride cotransporter 2 (KCC2) and sodium-potassium-chloride transporter (NKCC1).
Fichier principal
Vignette du fichier
2019 scheyer B Psy.pdf (1.95 Mo) Télécharger le fichier
Loading...

Dates and versions

hal-02389004 , version 1 (02-12-2019)

Identifiers

Cite

Andrew F Scheyer, Milene Borsoi, Jim Wager-Miller, Anne-Laure Pélissier-Alicot, Michelle N Murphy, et al.. Journal Pre-proof Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors. Biological Psychiatry, 2019, ⟨10.1016/j.biopsych.2019.08.023⟩. ⟨hal-02389004⟩
61 View
136 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More