We analyzed for the first time the effect of variations in the number of air hole rings and the filling factor of twisted microstructured optical fibers on the resonant couplings between fundamental and cladding modes. Rigorous numerical simulations show that these parameters can be used to control the spectral width of the resonance peaks, resonance loss, and relative strength of polarization effects. Furthermore, the number of air hole rings has a decisive impact on the number of twist-induced resonances and their wavelength range.