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Journal Articles Journal of Gynecology Obstetrics and Human Reproduction Year : 2020

A snapshot of the Covid-19 pandemic among pregnant women in France

1 CHU Trousseau [APHP]
2 MEPHI - Microbes évolution phylogénie et infections
3 Service de Gynécologie et Obstétrique [Marseille]
4 Maternité Port-Royal [CHU Cochin]
5 Groupe Hospitalier Paris Saint Joseph
6 APHM - Assistance Publique - Hôpitaux de Marseille
7 BREST - Gynéco-Obs - Service de Gynécologie-Obstétrique
8 CHU Tenon [AP-HP]
9 UPD7 - Université Paris Diderot - Paris 7
10 SAINBIOSE - Santé Ingénierie Biologie Saint-Etienne
11 UP11 - Université Paris-Sud - Paris 11
12 Hôpital Jeanne de Flandre [Lille]
13 Service de Gynécologie-Obstétrique, Pôle Parents Enfants,Hôpital Saint-Joseph,
14 HCL - Hospices Civils de Lyon
15 Service de Gynécologie-Obstétrique et Médecine de la Reproduction [CHU Caen]
16 UMR_S 953 - Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants
17 UP13 - Université Paris 13
18 Pôle Entrepreneuriat et Innovation - Rouen Business School
19 LAMIH - Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201
20 SBRI - Institut cellule souche et cerveau / Stem Cell and Brain Research Institute
21 BREED - Biologie de la Reproduction, Environnement, Epigénétique & Développement
22 RISCQ - Risques cliniques et sécurité en santé des femmes et en santé périnatale
23 Le2i - Laboratoire Electronique, Informatique et Image [UMR6306]
24 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
25 Association diagnostic prévention - Groupe de Recherche sur les Infections pendant la Grossesse [Vélizy-Villacoublay]
26 Service de Gynécologie-Obstétrique [Bicêtre]
27 Service de gynécologie-obstétrique
28 Service Obstétrique [CHU Toulouse]
30 Service de Gynécologie et Obstétrique [CHU Rouen]
31 U 1169 - Thérapie génique, Génomique et Epigénomique
32 Hôpital Mère Enfant CHU Nantes
33 PhAN - Physiopathologie des Adaptations Nutritionnelles
Gilles Kayem
Thomas Schmitz
  • Function : Author
Vivien Alessandrini
  • Function : Author
  • PersonId : 1052282
Elie Azria
  • Function : Author
  • PersonId : 976408
Marie Bornes
  • Function : Author
Yasmine Chalet
  • Function : Author
Philippe Deruelle
Loïc Sentilhes
Jeremy Sroussi
  • Function : Author


Objective To describe the course over time of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in French women from the beginning of the pandemic until mid-April, the risk profile of women with respiratory complications, and short-term pregnancy outcomes. Methods We collected a case series of pregnant women with COVID-19 in a research network of 33 French maternity units between March 1 and April 14, 2020. All cases of SARS-CoV-2 infection confirmed by a positive result on real-time reverse transcriptase polymerase chain reaction tests of a nasal sample and/or diagnosed by a computed tomography chest scan were included and analyzed. The primary outcome measures were COVID-19 requiring oxygen (oxygen therapy or noninvasive ventilation) and critical COVID-19 (requiring invasive mechanical ventilation or extracorporeal membrane oxygenation, ECMO). Demographic data, baseline comorbidities, and pregnancy outcomes were also collected. Results Active cases of COVID-19 increased exponentially during March 1–31, 2020; the numbers fell during April 1–14, after lockdown was imposed on March 17. The shape of the curve of active critical COVID-19 mirrored that of all active cases. By April 14, among the 617 pregnant women with COVID-19, 93 women (15.1 %; 95 %CI 12.3–18.1) had required oxygen therapy and 35 others (5.7 %; 95 %CI 4.0–7.8) had had a critical form of COVID-19. The severity of the disease was associated with age older than 35 years and obesity, as well as preexisting diabetes, previous preeclampsia, and gestational hypertension or preeclampsia. One woman with critical COVID-19 died (0.2 %; 95 %CI 0−0.9). Among the women who gave birth, rates of preterm birth in women with non-severe, oxygen-requiring, and critical COVID-19 were 13/123 (10.6 %), 14/29 (48.3 %), and 23/29 (79.3 %) before 37 weeks and 3/123 (2.4 %), 4/29 (13.8 %), and 14/29 (48.3 %) before 32 weeks, respectively. One neonate (0.5 %; 95 %CI 0.01–2.9) in the critical group died from prematurity. Conclusion COVID-19 can be responsible for significant rates of severe acute, potentially deadly, respiratory distress syndromes. The most vulnerable pregnant women, those with comorbidities, may benefit particularly from prevention measures such as a lockdown.
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hal-02869022 , version 1 (22-08-2022)


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Gilles Kayem, Florence Bretelle, Thomas Schmitz, Vivien Alessandrini, Elie Azria, et al.. A snapshot of the Covid-19 pandemic among pregnant women in France. Journal of Gynecology Obstetrics and Human Reproduction, 2020, 49 (7), pp.101826. ⟨10.1016/j.jogoh.2020.101826⟩. ⟨hal-02869022⟩
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