Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital - Aix-Marseille Université Access content directly
Journal Articles Future Microbiology Year : 2020

Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital

Jad El Tom
  • Function : Author
Elie B. Raad
  • Function : Author
Ahmad Al Atrouni
  • Function : Author
Monzer Hamze

Abstract

Aim: We sought to investigate the genetic epidemiological relatedness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains of a suspected outbreak in a Lebanese tertiary care hospital to implement necessary infection prevention and control measures. Methods: Twenty-eight nonduplicate CRAB isolates detected among hospitalized patients between January 2016 and July 2017 were studied by real-time polymerase chain reaction (PCR), pulsed-field gel electrophoresis and multilocus sequence typing analyses. Results: Twenty-seven isolates harbored bla(OXA-23). of which one also carried bla(NDM-1). The isolates distributed temporally in two presumably episodes were stratified by pulsed-field gel electrophoresis into many clusters. Although several clones have become endemic in the hospital, we have rapidly implemented appropriate infection prevention and control measures, achieving full eradication from August 2017 to November 2019. Conclusion: We have successfully investigated and controlled a polyclonal outbreak of OXA-23 producing ST2 CRAB.
No file

Dates and versions

hal-03149247 , version 1 (22-02-2021)

Identifiers

Cite

Marwan Osman, Fatima B. Halimeh, Rayane Rafei, Hassan Mallat, Jad El Tom, et al.. Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital. Future Microbiology, 2020, 15 (16), pp.1535-1542. ⟨10.2217/fmb-2020-0079⟩. ⟨hal-03149247⟩
43 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More