A comparative genomics study of 23 Aspergillus species from section Flavi - Aix-Marseille Université Access content directly
Journal Articles Nature Communications Year : 2020

A comparative genomics study of 23 Aspergillus species from section Flavi

Tammi Vesth
  • Function : Author
Jens Frisvad
  • Function : Author
Jane Nybo
  • Function : Author
Alan Kuo
Atsushi Sato
  • Function : Author
Ellen Lyhne
  • Function : Author
Martin Kogle
  • Function : Author
Ad Wiebenga
  • Function : Author
Roland Kun
  • Function : Author
Ronnie Lubbers
  • Function : Author
Miia Mäkelä
  • Function : Author
Kerrie Barry
Sajeet Haridas
Kurt Labutti
Anna Lipzen
Jon Magnuson
Thomas Larsen
  • Function : Author
Ronald de Vries
  • Function : Author
Igor Grigoriev

Abstract

Section Flavi encompasses both harmful and beneficial Aspergillus species, such as Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus flavus, food spoiler and mycotoxin producer. Here, we sequence 19 genomes spanning section Flavi and compare 31 fungal genomes including 23 Flavi species. We reassess their phylogenetic relationships and show that the closest relative of A. oryzae is not A. flavus, but A. minisclerotigenes or A. aflatoxiformans and identify high genome diversity, especially in sub-telomeric regions. We predict abundant CAZymes (598 per species) and prolific secondary metabolite gene clusters (73 per species) in section Flavi. However, the observed phenotypes (growth characteristics, polysaccharide degradation) do not necessarily correlate with inferences made from the predicted CAZyme content. Our work, including genomic analyses, phenotypic assays, and identification of secondary metabolites, highlights the genetic and metabolic diversity within section Flavi.

Dates and versions

hal-03162772 , version 1 (08-03-2021)

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Inge Kjærbølling, Tammi Vesth, Jens Frisvad, Jane Nybo, Sebastian Theobald, et al.. A comparative genomics study of 23 Aspergillus species from section Flavi. Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-019-14051-y⟩. ⟨hal-03162772⟩
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