fosM , a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota - Aix-Marseille Université Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2021

fosM , a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota

Abstract

ABSTRACT Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined in vitro/in silico approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Escherichia coli strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named fosM .

Dates and versions

hal-03216141 , version 1 (03-05-2021)

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Sami Khabthani, Mouna Hamel, Sophie Alexandra Baron, Seydina Diene, Jean-Marc Rolain, et al.. fosM , a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota. Antimicrobial Agents and Chemotherapy, 2021, 65 (2), ⟨10.1128/AAC.01712-20⟩. ⟨hal-03216141⟩

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