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Journal Articles New Microbes and New Infections Year : 2021

Unraveling the origin of SARS-CoV-2: is the model good?

Abstract

MacLean and colleagues recently published a very elegant analysis demonstrating that SARS-CoV-2 carries signs of positive selection and that it was already adapted to humans prior to the emergence of COVID-19. Using the Spillover theory as a reference model for zoonotic emergence, they conclude that SARS-CoV-2 must have acquired this human adaptation in bats. We reinterpreted the data from MacLean et al. using a different model of zoonotic emergence as reference, the Circulation model. The use of the Circulation model provides a more parsimonious interpretation showing that this adaptation to humans occurs in the human population after primo infection.
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Dates and versions

hal-03300039 , version 1 (06-09-2021)

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Attribution - NonCommercial - NoDerivatives

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Roger Frutos, Laurent Gavotte, Christian Devaux. Unraveling the origin of SARS-CoV-2: is the model good?. New Microbes and New Infections, 2021, pp.100918. ⟨10.1016/j.nmni.2021.100918⟩. ⟨hal-03300039⟩
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