Unraveling the origin of SARS-CoV-2: is the model good? - Aix-Marseille Université Access content directly
Journal Articles New Microbes and New Infections Year : 2021

Unraveling the origin of SARS-CoV-2: is the model good?


MacLean and colleagues recently published a very elegant analysis demonstrating that SARS-CoV-2 carries signs of positive selection and that it was already adapted to humans prior to the emergence of COVID-19. Using the Spillover theory as a reference model for zoonotic emergence, they conclude that SARS-CoV-2 must have acquired this human adaptation in bats. We reinterpreted the data from MacLean et al. using a different model of zoonotic emergence as reference, the Circulation model. The use of the Circulation model provides a more parsimonious interpretation showing that this adaptation to humans occurs in the human population after primo infection.
Fichier principal
Vignette du fichier
1-s2.0-S2052297521000822-main.pdf (536.43 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03300039 , version 1 (06-09-2021)


Attribution - NonCommercial - NoDerivatives



Roger Frutos, Laurent Gavotte, Christian Devaux. Unraveling the origin of SARS-CoV-2: is the model good?. New Microbes and New Infections, 2021, pp.100918. ⟨10.1016/j.nmni.2021.100918⟩. ⟨hal-03300039⟩
164 View
98 Download



Gmail Facebook X LinkedIn More