Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension - Aix-Marseille Université Access content directly
Journal Articles The Lancet Neurology Year : 2018

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Raju Kapoor (1) , Pei-Ran Ho (2) , Nolan Campbell (2) , Ih Chang (2) , Aaron Deykin (2) , Fiona Forrestal (2) , Nisha Lucas (2) , Bei Yu (2) , Douglas Arnold (3) , Mark Freedman (4) , Myla Goldman (5) , Hans-Peter Hartung (6) , Eva Kubala Havrdová (7) , Douglas Jeffery (8) , Aaron Miller (9) , Finn Sellebjerg (10) , Diego Cadavid (2) , Dan Mikol (2) , Deborah Steiner (2) , Emmanuel Bartholomé , Marie d'Hooghe , Massimo Pandolfo , Bart van Wijmeersch , Virender Bhan , Gregg Blevins , Donald Brunet , Virginia Devonshire , Pierre Duquette , François Grand'Maison , François Jacques , Yves Lapierre , Liesly Lee , Sarah Morrow , Michael Yeung , Michal Dufek , Petr Kanovsky , Ivana Stetkarova , Marika Talabova , Jette Frederiksen , Matthias Kant , Thor Petersen , Mads Ravnborg , Laura Airas , Irina Elovaara , Juha-Pekka Eralinna , Taneli Sarasoja , Abdullatif Al Khedr , David Brassat , Bruno Brochet , William Camu , Marc Debouverie , David Laplaud , Christine Lebrun Frenay , Jean Pelletier (11, 12, 13) , Patrick Vermersch , Sandra Vukusi , Karl Baum , Achim Berthele , Juergen Faiss , Peter Flachenecker , Reinhard Hohlfeld , Markus Krumbholz , Christoph Lassek , Mathias Maeurer , Sven Meuth , Tjalf Ziemssen , Orla Hardiman , Christopher Mcguigan , Anat Achiron , Dimitrios Karussis , Roberto Bergamaschi , Vincenzo Brescia Morra , Giancarlo Comi , Salvatore Cottone , Luigi Grimaldi , Giovanni Luigi Mancardi , Luca Massacesi , Ugo Nocentini , Marco Salvetti , Elio Scarpini , Patrizia Sola , Gioacchino Tedeschi , Maria Trojano , Mauro Zaffaroni , Stephan Frequin , Raymond Hupperts , Joep Killestein , Hans Schrijver , Ronald van Dijl , Erik van Munster , Maciej Czarnecki , Wieslaw Drozdowski , Waldemar Fryze , Hanka Hertmanowska , Jan Ilkowski , Anna Kaminska , Gabriela Klodowska-Duda , Maciej Maciejowski , Ewa Motta , Ryszard Podemski , Andrzej Potemkowski , Teresa Rog , Krzysztof Selmaj , Zbigniew Stelmasiak , Adam Stepien , Andrzej Tutaj , Jacek Zaborski , Alexey Boyko , Zanna Chefranova , Evgeny Evdoshenko , Farit Khabirov , Stella Sivertseva , Eduard Yakupov , Jose Carlos Alvarez Cermeño , Antonio Escartin , Oscar Fernandez Fernandez , Antonio Garcia-Merino , Miguel Angel Hernandez Perez , Guillermo Izquierdo Ayuso , José Meca Lallana , Xavier Montalban Gairin , Celia Oreja-Guevara , Albert Saiz Hinarejos , Martin Gunnarsson , Jan Lycke , Claes Martin , Fredrik Piehl , Homayoun Roshanisefat , Peter Sundstrom , Martin Duddy , Bruno Gran , Timothy Harrower , Jeremy Hobart , Martin Lee , Paul Mattison , Richard Nicholas , Owen Pearson , Waqar Rashid , David Rog , Basil Sharrack , Eli Silber , Ben Turner , Anna Williams , John Woolmore , Carolyn Young , Daniel Bandari , Joseph Berger , Ann Camac , Stanley Cohan , Jill Conway , Keith Edwards , Michelle Fabian , Jack Florin , Steven Freedman , Dennis Garwacki , Daniel Harrison , Craig Herrman , Deren Huang , Adil Javed , Stephen Kamin , George Katsamakis , Bhupendra Khatri , Annette Langer-Gould , Sharon Lynch , David Mattson , Tamara Miller , Augusto Miravalle , Harold Moses , Suraj Muley , James Napier , Allen Nielsen , Andrew Pachner , Gabriel Pardo , Maryann Picone , Derrick Robertson , Walter Royal , Christopher Sheppard , Ben Thrower , Cary Twyman , Emmanuelle Waubant , Jeanette Wendt , Vijayshree Yadav , Rana Zabad , Greg Zarelli
Emmanuel Bartholomé
  • Function : Author
Marie d'Hooghe
  • Function : Author
Massimo Pandolfo
  • Function : Author
Bart van Wijmeersch
  • Function : Author
Virender Bhan
  • Function : Author
Gregg Blevins
  • Function : Author
Donald Brunet
  • Function : Author
Virginia Devonshire
  • Function : Author
Pierre Duquette
  • Function : Author
François Grand'Maison
  • Function : Author
François Jacques
  • Function : Author
Yves Lapierre
  • Function : Author
Liesly Lee
  • Function : Author
Sarah Morrow
  • Function : Author
Michael Yeung
  • Function : Author
Michal Dufek
  • Function : Author
Petr Kanovsky
  • Function : Author
Ivana Stetkarova
  • Function : Author
Marika Talabova
  • Function : Author
Jette Frederiksen
  • Function : Author
Matthias Kant
  • Function : Author
Thor Petersen
  • Function : Author
Mads Ravnborg
  • Function : Author
Laura Airas
  • Function : Author
Irina Elovaara
  • Function : Author
Juha-Pekka Eralinna
  • Function : Author
Taneli Sarasoja
  • Function : Author
Abdullatif Al Khedr
  • Function : Author
David Brassat
Bruno Brochet
William Camu
  • Function : Author
Marc Debouverie
  • Function : Author
  • PersonId : 762777
  • IdRef : 068986629
David Laplaud
  • Function : Author
Christine Lebrun Frenay
  • Function : Author
Patrick Vermersch
Sandra Vukusi
  • Function : Author
Karl Baum
  • Function : Author
Achim Berthele
Juergen Faiss
  • Function : Author
Peter Flachenecker
  • Function : Author
Reinhard Hohlfeld
Markus Krumbholz
  • Function : Author
Christoph Lassek
  • Function : Author
Mathias Maeurer
  • Function : Author
Sven Meuth
Tjalf Ziemssen
  • Function : Author
Orla Hardiman
Christopher Mcguigan
  • Function : Author
Anat Achiron
  • Function : Author
Dimitrios Karussis
  • Function : Author
Roberto Bergamaschi
  • Function : Author
Vincenzo Brescia Morra
  • Function : Author
Giancarlo Comi
  • Function : Author
Salvatore Cottone
  • Function : Author
Luigi Grimaldi
  • Function : Author
Giovanni Luigi Mancardi
  • Function : Author
Luca Massacesi
  • Function : Author
Ugo Nocentini
  • Function : Author
Marco Salvetti
  • Function : Author
Elio Scarpini
  • Function : Author
Patrizia Sola
  • Function : Author
Gioacchino Tedeschi
  • Function : Author
Maria Trojano
  • Function : Author
Mauro Zaffaroni
  • Function : Author
Stephan Frequin
  • Function : Author
Raymond Hupperts
  • Function : Author
Joep Killestein
  • Function : Author
Hans Schrijver
  • Function : Author
Ronald van Dijl
  • Function : Author
Erik van Munster
  • Function : Author
Maciej Czarnecki
  • Function : Author
Wieslaw Drozdowski
  • Function : Author
Waldemar Fryze
  • Function : Author
Hanka Hertmanowska
  • Function : Author
Jan Ilkowski
  • Function : Author
Anna Kaminska
  • Function : Author
Gabriela Klodowska-Duda
  • Function : Author
Maciej Maciejowski
  • Function : Author
Ewa Motta
  • Function : Author
Ryszard Podemski
  • Function : Author
Andrzej Potemkowski
  • Function : Author
Teresa Rog
  • Function : Author
Krzysztof Selmaj
  • Function : Author
Zbigniew Stelmasiak
  • Function : Author
Adam Stepien
  • Function : Author
Andrzej Tutaj
  • Function : Author
Jacek Zaborski
  • Function : Author
Alexey Boyko
  • Function : Author
Zanna Chefranova
  • Function : Author
Evgeny Evdoshenko
  • Function : Author
Farit Khabirov
  • Function : Author
Stella Sivertseva
  • Function : Author
Eduard Yakupov
  • Function : Author
Jose Carlos Alvarez Cermeño
  • Function : Author
Antonio Escartin
  • Function : Author
Oscar Fernandez Fernandez
  • Function : Author
Antonio Garcia-Merino
  • Function : Author
Miguel Angel Hernandez Perez
  • Function : Author
Guillermo Izquierdo Ayuso
  • Function : Author
José Meca Lallana
  • Function : Author
Xavier Montalban Gairin
  • Function : Author
Celia Oreja-Guevara
  • Function : Author
Albert Saiz Hinarejos
  • Function : Author
Martin Gunnarsson
  • Function : Author
Jan Lycke
Claes Martin
  • Function : Author
Fredrik Piehl
  • Function : Author
Homayoun Roshanisefat
  • Function : Author
Peter Sundstrom
  • Function : Author
Martin Duddy
  • Function : Author
Bruno Gran
  • Function : Author
Timothy Harrower
  • Function : Author
Jeremy Hobart
  • Function : Author
Martin Lee
  • Function : Author
Paul Mattison
  • Function : Author
Richard Nicholas
  • Function : Author
Owen Pearson
  • Function : Author
Waqar Rashid
  • Function : Author
David Rog
  • Function : Author
Basil Sharrack
  • Function : Author
Eli Silber
  • Function : Author
Ben Turner
  • Function : Author
Anna Williams
  • Function : Author
John Woolmore
  • Function : Author
Carolyn Young
  • Function : Author
Daniel Bandari
  • Function : Author
Joseph Berger
  • Function : Author
Ann Camac
  • Function : Author
Stanley Cohan
  • Function : Author
Jill Conway
  • Function : Author
Keith Edwards
  • Function : Author
Michelle Fabian
  • Function : Author
Jack Florin
  • Function : Author
Steven Freedman
  • Function : Author
Dennis Garwacki
  • Function : Author
Daniel Harrison
  • Function : Author
Craig Herrman
  • Function : Author
Deren Huang
  • Function : Author
Adil Javed
  • Function : Author
Stephen Kamin
  • Function : Author
George Katsamakis
  • Function : Author
Bhupendra Khatri
  • Function : Author
Annette Langer-Gould
  • Function : Author
Sharon Lynch
  • Function : Author
David Mattson
  • Function : Author
Tamara Miller
  • Function : Author
Augusto Miravalle
  • Function : Author
Harold Moses
  • Function : Author
Suraj Muley
  • Function : Author
James Napier
  • Function : Author
Allen Nielsen
  • Function : Author
Andrew Pachner
  • Function : Author
Gabriel Pardo
  • Function : Author
Maryann Picone
  • Function : Author
Derrick Robertson
  • Function : Author
Walter Royal
  • Function : Author
Christopher Sheppard
  • Function : Author
Ben Thrower
  • Function : Author
Cary Twyman
  • Function : Author
Emmanuelle Waubant
  • Function : Author
Jeanette Wendt
  • Function : Author
Vijayshree Yadav
  • Function : Author
Rana Zabad
  • Function : Author
Greg Zarelli
  • Function : Author

Dates and versions

hal-03541622 , version 1 (24-01-2022)

Identifiers

Cite

Raju Kapoor, Pei-Ran Ho, Nolan Campbell, Ih Chang, Aaron Deykin, et al.. Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension. The Lancet Neurology, 2018, 17 (5), pp.405-415. ⟨10.1016/S1474-4422(18)30069-3⟩. ⟨hal-03541622⟩
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