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Journal Articles The Lancet Year : 2018

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Ludwig Kappos (1) , Amit Bar-Or (2, 3) , Bruce Cree (4) , Robert Fox (5) , Gavin Giovannoni (6) , Ralf Gold (7) , Patrick Vermersch (8) , Douglas Arnold (9) , Sophie Arnould (10) , Tatiana Scherz (10) , Christian Wolf (11) , Erik Wallström (10) , Frank Dahlke (10) , Anat Achiron , Lutz Achtnichts , Kadriye Agan , Gulsen Akman-Demir , Alison Allen , Jack Antel , Alfredo Rodriguez Antiguedad , Michelle Apperson , Angela Applebee , Guillermo Izquierdo Ayuso , Masayuki Baba , Ovidiu Bajenaru , Rodica Balasa , Belgin Petek Balci , Michael Barnett , Ann Bass , Veit Becker , Mihaela Bejinariu , Florian Then Bergh , Arnfin Bergmann , Evanthia Bernitsas , Achim Berthele , Virender Bhan , Felix Bischof , Randall John Bjork , Gregg Blevins , Matthias Boehringer , Thomas Boerner , Robert Bonek , James Bowen , Allen Bowling , Alexey Boyko , Cavit Boz , Vera Bracknies , Stefan Braune , Vincenzo Brescia Morra , Bruno Brochet , Waldemar Brola , Paul Kenneth Brownstone , Miroslav Brozman , Donald Brunet , Ioan Buraga , Margaret Burnett , Mathias Buttmann , Helmut Butzkueven , Jonathan Cahill , Jonathan Calkwood , William Camu , Mark Cascione , Giovani Castelnovo , Diego Centonze , Joao Cerqueira , Andrew Chan , Andrea Cimprichova , Stanley Cohan , Giancarlo Comi , Jill Conway , Joanna Cooper , John Corboy , Jorge Correale , Brian Costell , David Cottrell , Patricia Coyle , Matthew Craner , Liying Cui , Luis Cunha , Anna Czlonkowska , Ana Martins da Silva , Joao de Sa , Jérôme de Seze , Marc Debouverie , Jan Debruyne , Danny Decoo , Gilles Defer , Tobias Derfuss , Norma Deri , Bhupesh Dihenia , Peter Dioszeghy , Vladimir Donath , Benedicte Dubois , Martin Duddy , Pierre Duquette , Gilles Edan , Husnu Efendi , Stanton Elias , Peter Emrich , Bonaventura Casanova Estruch , Evgeniy Evdoshenko , Juergen Faiss , Alexander Fedyanin , Wolfgang Feneberg , Jiske Fermont , Oscar Fernandez Fernandez , Francisco Coret Ferrer , Katharina Fink , Helen Ford , Corey Ford , Ada Francia , Mark Freedman , Benjamin Frishberg , Simonetta Galgani , George Garmany , Klaus Gehring , Jeffrey Gitt , Claudio Gobbi , Lawrence Goldstick , Rafael Arroyo Gonzalez , Francois Grandmaison , Nikolaos Grigoriadis , Olga Grigorova , Luigi Maria Edoardo Grimaldi , Jeffrey Gross , Katrin Gross-Paju , Mark Gudesblatt , Daniel Guillaume , Judith Haas , Viera Hancinova , Anca Hancu , Orla Hardiman , Arndt Harmjanz , Fedor Heidenreich , G Hengstman , Joseph Herbert , Mark Herring , Suzanne Hodgkinson , Olaf Hoffmann , Werner Hofmann , William Honeycutt , Le Hanh Hua , Dehui Huang , Yining Huang , Deren Huang , Raymond Hupperts , Piroska Imre , Alan Keith Jacobs , Gabor Jakab , Elzbieta Jasinska , Kenichi Kaida , Jolanta Kalnina , Ara Kaprelyan , Guntis Karelis , Dimitrios Karussis , Amos Katz , Farit Khabirov , Bhupendra Khatri , Takashi Kimura , Ilya Kister , Rasa Kizlaitiene , Eleonora Klimova , Juergen Koehler , Aparna Komatineni , Anselm Kornhuber , Krisztina Kovacs , Agnes Koves , Wojciech Kozubski , Georgi Krastev , Lauren Krupp , Egon Kurca , Christoph Lassek , Guy Laureys , Liesly Lee , Eckart Lensch , Fritz Leutmezer , Hongzeng Li , Ralf Linker , Michael Linnebank , Petra Liskova , Cristina Llanera , Jiahong Lu , Andreas Lutterotti , Jan Lycke , Richard Macdonell , Maciej Maciejowski , Mathias Maeurer , Rim Magzhanov , Eva-Maria Maida , Lina Malciene , Yang Mao-Draayer , Girolama Alessandra Marfia , Clyde Markowitz , Vasileios Mastorodimos , Klotild Matyas , Jose Meca-Lallana , Juan Antonio Garcia Merino , Ioan Gheorghe Mihetiu , Ivan Milanov , Aaron Miller , Andrejs Millers , Massimiliano Mirabella , Masanori Mizuno , Xavier Montalban , Lilina Montoya , Masahiro Mori , Stefanie Mueller , Jin Nakahara , Yuji Nakatsuji , Scott Newsome , Richard Nicholas , a Scott Nielsen , Esmaeil Nikfekr , Ugo Nocentini , Chiyoko Nohara , Kyoichi Nomura , Miroslav Odinak , Tomas Olsson , B van Oosten , Celia Oreja-Guevara , Patrick Oschmann , James Overell , Andrew Pachner , Gyula Panczel , Massimo Pandolfo , Caroline Papeix , Liliana Patrucco , Jean Pelletier (12, 13, 14) , Raul Piedrabuena , Misha Pless , Udo Polzer , Krisztian Pozsegovits , Daiva Rastenyte , Sebastian Rauer , Gerd Reifschneider , Roberto Rey , Syed Rizvi , Derrick Robertson , Jose Martinez Rodriguez , David Rog , Homayoun Roshanisefat , Vernon Rowe , Csilla Rozsa , Susan Rubin , Stanislaw Rusek , Francesco Saccà , Takahiko Saida , Antonio Vasco Salgado , Victoria Eugenia Fernandez Sanchez , Kalina Sanders , Maria Satori , Denis Sazonov , Elio Angelo Scarpini , Eugen Schlegel , Myriam Schluep , Stephan Schmidt , Erich Scholz , H Schrijver , Matthias Schwab , Raymond Schwartz , James Scott , Krzysztof Selmaj , Stuart Shafer , Basil Sharrack , Ivan Shchukin , Yuko Shimizu , Penko Shotekov , Arno Siever , Karl-Otto Sigel , Scott Silliman , Magdolna Simo , Mihaela Simu , Vladimiro Sinay , Antonio Escartin Siquier , Aksel Siva , Ondrej Skoda , Andrew Solomon , Martin Stangel , Dusan Stefoski , Brian Steingo , Igor Stolyarov , Pavel Stourac , Katrin Strassburger-Krogias , Erik Strauss , Olaf Stuve , Ivaylo Tarnev , Antonios Tavernarakis , Cristina Ramo Tello , Murat Terzi , Veronika Ticha , Marina Ticmeanu , Klaus Tiel-Wilck , Toomas Toomsoo , Niall Tubridy , Mark Tullman , Hayrettin Tumani , Peter Turcani , Ben Turner , Antonio Uccelli , Francisco Javier Olascoaga Urtaza , Marta Vachova , Attila Valikovics , Silke Walter , Bart van Wijmeersch , Ludo Vanopdenbosch , Joerg Weber , Sara Weiss , Robert Weissert , Timothy West , Heinz Wiendl , Sandrine Wiertlewski , Brigitte Wildemann , Barbara Willekens , L Visser , Galina Vorobeychik , Xianhao Xu , Takashi Yamamura , Yi Yang , Sergio Martinez Yelamos , Michael Yeung , Alan Zacharias , Marvin Zelkowitz , Uwe Zettl , Meini Zhang , Hongyu Zhou , Ulf Zieman , Tjalf Ziemssen
Christian Wolf
Frank Dahlke
  • Function : Author
Anat Achiron
  • Function : Author
Lutz Achtnichts
  • Function : Author
Kadriye Agan
  • Function : Author
Gulsen Akman-Demir
  • Function : Author
Alison Allen
  • Function : Author
Jack Antel
  • Function : Author
Alfredo Rodriguez Antiguedad
  • Function : Author
Michelle Apperson
  • Function : Author
Angela Applebee
  • Function : Author
Guillermo Izquierdo Ayuso
  • Function : Author
Masayuki Baba
  • Function : Author
Ovidiu Bajenaru
  • Function : Author
Rodica Balasa
  • Function : Author
Belgin Petek Balci
  • Function : Author
Michael Barnett
  • Function : Author
Ann Bass
  • Function : Author
Veit Becker
  • Function : Author
Mihaela Bejinariu
  • Function : Author
Florian Then Bergh
  • Function : Author
Arnfin Bergmann
  • Function : Author
Evanthia Bernitsas
  • Function : Author
Achim Berthele
Virender Bhan
  • Function : Author
Felix Bischof
  • Function : Author
Randall John Bjork
  • Function : Author
Gregg Blevins
  • Function : Author
Matthias Boehringer
  • Function : Author
Thomas Boerner
  • Function : Author
Robert Bonek
  • Function : Author
James Bowen
  • Function : Author
Allen Bowling
  • Function : Author
Alexey Boyko
  • Function : Author
Cavit Boz
  • Function : Author
Vera Bracknies
  • Function : Author
Stefan Braune
  • Function : Author
Vincenzo Brescia Morra
  • Function : Author
Bruno Brochet
Waldemar Brola
Paul Kenneth Brownstone
  • Function : Author
Miroslav Brozman
  • Function : Author
Donald Brunet
  • Function : Author
Ioan Buraga
  • Function : Author
Margaret Burnett
  • Function : Author
Mathias Buttmann
  • Function : Author
Helmut Butzkueven
  • Function : Author
Jonathan Cahill
  • Function : Author
Jonathan Calkwood
  • Function : Author
William Camu
  • Function : Author
Mark Cascione
  • Function : Author
Giovani Castelnovo
  • Function : Author
Diego Centonze
  • Function : Author
Joao Cerqueira
  • Function : Author
Andrew Chan
  • Function : Author
Andrea Cimprichova
  • Function : Author
Stanley Cohan
  • Function : Author
Giancarlo Comi
  • Function : Author
Jill Conway
  • Function : Author
Joanna Cooper
  • Function : Author
John Corboy
  • Function : Author
Jorge Correale
  • Function : Author
Brian Costell
  • Function : Author
David Cottrell
  • Function : Author
Patricia Coyle
  • Function : Author
Matthew Craner
  • Function : Author
Liying Cui
  • Function : Author
Luis Cunha
  • Function : Author
Anna Czlonkowska
  • Function : Author
Ana Martins da Silva
  • Function : Author
Joao de Sa
  • Function : Author
Jérôme de Seze
  • Function : Author
Marc Debouverie
  • Function : Author
  • PersonId : 762777
  • IdRef : 068986629
Jan Debruyne
  • Function : Author
Danny Decoo
  • Function : Author
Gilles Defer
  • Function : Author
Tobias Derfuss
  • Function : Author
Norma Deri
  • Function : Author
Bhupesh Dihenia
  • Function : Author
Peter Dioszeghy
  • Function : Author
Vladimir Donath
  • Function : Author
Benedicte Dubois
  • Function : Author
Martin Duddy
  • Function : Author
Pierre Duquette
  • Function : Author
Gilles Edan
  • Function : Author
Husnu Efendi
  • Function : Author
Stanton Elias
  • Function : Author
Peter Emrich
  • Function : Author
Bonaventura Casanova Estruch
  • Function : Author
Evgeniy Evdoshenko
  • Function : Author
Juergen Faiss
  • Function : Author
Alexander Fedyanin
  • Function : Author
Wolfgang Feneberg
  • Function : Author
Jiske Fermont
  • Function : Author
Oscar Fernandez Fernandez
  • Function : Author
Francisco Coret Ferrer
  • Function : Author
Katharina Fink
  • Function : Author
Helen Ford
  • Function : Author
Corey Ford
  • Function : Author
Ada Francia
  • Function : Author
Mark Freedman
  • Function : Author
Benjamin Frishberg
  • Function : Author
Simonetta Galgani
  • Function : Author
George Garmany
  • Function : Author
Klaus Gehring
  • Function : Author
Jeffrey Gitt
  • Function : Author
Claudio Gobbi
  • Function : Author
Lawrence Goldstick
  • Function : Author
Rafael Arroyo Gonzalez
  • Function : Author
Francois Grandmaison
  • Function : Author
Nikolaos Grigoriadis
  • Function : Author
Olga Grigorova
  • Function : Author
Luigi Maria Edoardo Grimaldi
  • Function : Author
Jeffrey Gross
  • Function : Author
Katrin Gross-Paju
  • Function : Author
Mark Gudesblatt
  • Function : Author
Daniel Guillaume
  • Function : Author
Judith Haas
  • Function : Author
Viera Hancinova
  • Function : Author
Anca Hancu
  • Function : Author
Orla Hardiman
Arndt Harmjanz
  • Function : Author
Fedor Heidenreich
  • Function : Author
G Hengstman
  • Function : Author
Joseph Herbert
  • Function : Author
Mark Herring
  • Function : Author
Suzanne Hodgkinson
  • Function : Author
Olaf Hoffmann
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Werner Hofmann
  • Function : Author
William Honeycutt
  • Function : Author
Le Hanh Hua
  • Function : Author
Dehui Huang
  • Function : Author
Yining Huang
Deren Huang
  • Function : Author
Raymond Hupperts
  • Function : Author
Piroska Imre
  • Function : Author
Alan Keith Jacobs
  • Function : Author
Gabor Jakab
  • Function : Author
Elzbieta Jasinska
  • Function : Author
Kenichi Kaida
  • Function : Author
Jolanta Kalnina
  • Function : Author
Ara Kaprelyan
  • Function : Author
Guntis Karelis
  • Function : Author
Dimitrios Karussis
  • Function : Author
Amos Katz
  • Function : Author
Farit Khabirov
  • Function : Author
Bhupendra Khatri
  • Function : Author
Takashi Kimura
  • Function : Author
Ilya Kister
  • Function : Author
Rasa Kizlaitiene
  • Function : Author
Eleonora Klimova
  • Function : Author
Juergen Koehler
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Aparna Komatineni
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Anselm Kornhuber
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Krisztina Kovacs
  • Function : Author
Agnes Koves
  • Function : Author
Wojciech Kozubski
  • Function : Author
Georgi Krastev
  • Function : Author
Lauren Krupp
  • Function : Author
Egon Kurca
  • Function : Author
Christoph Lassek
  • Function : Author
Guy Laureys
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Liesly Lee
  • Function : Author
Eckart Lensch
  • Function : Author
Fritz Leutmezer
  • Function : Author
Hongzeng Li
  • Function : Author
Ralf Linker
  • Function : Author
Michael Linnebank
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Petra Liskova
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Cristina Llanera
  • Function : Author
Jiahong Lu
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Andreas Lutterotti
  • Function : Author
Jan Lycke
Richard Macdonell
  • Function : Author
Maciej Maciejowski
  • Function : Author
Mathias Maeurer
  • Function : Author
Rim Magzhanov
  • Function : Author
Eva-Maria Maida
  • Function : Author
Lina Malciene
  • Function : Author
Yang Mao-Draayer
  • Function : Author
Girolama Alessandra Marfia
  • Function : Author
Clyde Markowitz
  • Function : Author
Vasileios Mastorodimos
  • Function : Author
Klotild Matyas
  • Function : Author
Jose Meca-Lallana
  • Function : Author
Juan Antonio Garcia Merino
  • Function : Author
Ioan Gheorghe Mihetiu
  • Function : Author
Ivan Milanov
  • Function : Author
Aaron Miller
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Andrejs Millers
  • Function : Author
Massimiliano Mirabella
  • Function : Author
Masanori Mizuno
  • Function : Author
Xavier Montalban
  • Function : Author
Lilina Montoya
  • Function : Author
Masahiro Mori
  • Function : Author
Stefanie Mueller
  • Function : Author
Jin Nakahara
  • Function : Author
Yuji Nakatsuji
  • Function : Author
Scott Newsome
  • Function : Author
Richard Nicholas
  • Function : Author
a Scott Nielsen
  • Function : Author
Esmaeil Nikfekr
  • Function : Author
Ugo Nocentini
  • Function : Author
Chiyoko Nohara
  • Function : Author
Kyoichi Nomura
  • Function : Author
Miroslav Odinak
  • Function : Author
Tomas Olsson
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B van Oosten
  • Function : Author
Celia Oreja-Guevara
  • Function : Author
Patrick Oschmann
  • Function : Author
James Overell
  • Function : Author
Andrew Pachner
  • Function : Author
Gyula Panczel
  • Function : Author
Massimo Pandolfo
  • Function : Author
Caroline Papeix
Liliana Patrucco
  • Function : Author
Raul Piedrabuena
  • Function : Author
Misha Pless
  • Function : Author
Udo Polzer
  • Function : Author
Krisztian Pozsegovits
  • Function : Author
Daiva Rastenyte
  • Function : Author
Sebastian Rauer
  • Function : Author
Gerd Reifschneider
  • Function : Author
Roberto Rey
  • Function : Author
Syed Rizvi
  • Function : Author
Derrick Robertson
  • Function : Author
Jose Martinez Rodriguez
  • Function : Author
David Rog
  • Function : Author
Homayoun Roshanisefat
  • Function : Author
Vernon Rowe
  • Function : Author
Csilla Rozsa
  • Function : Author
Susan Rubin
  • Function : Author
Stanislaw Rusek
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Francesco Saccà
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Takahiko Saida
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Antonio Vasco Salgado
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Kalina Sanders
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Maria Satori
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Denis Sazonov
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Elio Angelo Scarpini
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Eugen Schlegel
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Myriam Schluep
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Stephan Schmidt
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Erich Scholz
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H Schrijver
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Matthias Schwab
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Raymond Schwartz
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James Scott
Krzysztof Selmaj
  • Function : Author
Stuart Shafer
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Basil Sharrack
  • Function : Author
Ivan Shchukin
  • Function : Author
Yuko Shimizu
  • Function : Author
Penko Shotekov
  • Function : Author
Arno Siever
  • Function : Author
Karl-Otto Sigel
  • Function : Author
Scott Silliman
  • Function : Author
Magdolna Simo
  • Function : Author
Mihaela Simu
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Vladimiro Sinay
  • Function : Author
Antonio Escartin Siquier
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Aksel Siva
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Ondrej Skoda
  • Function : Author
Andrew Solomon
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Martin Stangel
Dusan Stefoski
  • Function : Author
Brian Steingo
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Igor Stolyarov
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Pavel Stourac
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Katrin Strassburger-Krogias
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Erik Strauss
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Olaf Stuve
  • Function : Author
Ivaylo Tarnev
  • Function : Author
Antonios Tavernarakis
  • Function : Author
Cristina Ramo Tello
  • Function : Author
Murat Terzi
  • Function : Author
Veronika Ticha
  • Function : Author
Marina Ticmeanu
  • Function : Author
Klaus Tiel-Wilck
  • Function : Author
Toomas Toomsoo
  • Function : Author
Niall Tubridy
  • Function : Author
Mark Tullman
  • Function : Author
Hayrettin Tumani
Peter Turcani
  • Function : Author
Ben Turner
  • Function : Author
Antonio Uccelli
  • Function : Author
Marta Vachova
  • Function : Author
Attila Valikovics
  • Function : Author
Silke Walter
  • Function : Author
Bart van Wijmeersch
  • Function : Author
Ludo Vanopdenbosch
  • Function : Author
Joerg Weber
  • Function : Author
Sara Weiss
  • Function : Author
Robert Weissert
  • Function : Author
Timothy West
  • Function : Author
Heinz Wiendl
  • Function : Author
Sandrine Wiertlewski
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Brigitte Wildemann
  • Function : Author
Barbara Willekens
  • Function : Author
L Visser
  • Function : Author
Galina Vorobeychik
  • Function : Author
Xianhao Xu
  • Function : Author
Takashi Yamamura
  • Function : Author
Yi Yang
Sergio Martinez Yelamos
  • Function : Author
Michael Yeung
  • Function : Author
Alan Zacharias
  • Function : Author
Marvin Zelkowitz
  • Function : Author
Uwe Zettl
Meini Zhang
  • Function : Author
Hongyu Zhou
  • Function : Author
Ulf Zieman
  • Function : Author
Tjalf Ziemssen
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Dates and versions

hal-03541636 , version 1 (24-01-2022)

Identifiers

Cite

Ludwig Kappos, Amit Bar-Or, Bruce Cree, Robert Fox, Gavin Giovannoni, et al.. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. The Lancet, 2018, 391 (10127), pp.1263-1273. ⟨10.1016/S0140-6736(18)30475-6⟩. ⟨hal-03541636⟩
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