Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3 + CD8 + T regs
Thorsten Joeris
(1, 2)
,
Cristina Gomez-Casado
(2)
,
Petra Holmkvist
(2)
,
Simon Tavernier
(3, 4)
,
Aaron Silva-Sanchez
(5)
,
Luisa Klotz
(6)
,
Troy Randall
(7)
,
Allan Mowat
(8)
,
Knut Kotarsky
(2)
,
Bernard Malissen
(9)
,
William Agace
(2, 1)
1
Department of Health Technology, Technical University of Denmark
2 Skane University Hospital [Lund]
3 Ghent University Hospital
4 IRC - VIB-UGent Center for Inflammation Research [Gand, Belgique]
5 University of Alabama at Birmingham, department od Medicine
6 UKM - University Hospital Münster - Universitaetsklinikum Muenster [Germany]
7 University of Alabama at Birmingham - Department of Medicine
8 University of Glasgow - Institute of Infection, Immunity and Inflammation
9 CIML - Centre d'Immunologie de Marseille - Luminy
2 Skane University Hospital [Lund]
3 Ghent University Hospital
4 IRC - VIB-UGent Center for Inflammation Research [Gand, Belgique]
5 University of Alabama at Birmingham, department od Medicine
6 UKM - University Hospital Münster - Universitaetsklinikum Muenster [Germany]
7 University of Alabama at Birmingham - Department of Medicine
8 University of Glasgow - Institute of Infection, Immunity and Inflammation
9 CIML - Centre d'Immunologie de Marseille - Luminy
Thorsten Joeris
- Function : Author
- PersonId : 780456
- ORCID : 0000-0002-1166-5871
Cristina Gomez-Casado
- Function : Author
- PersonId : 822425
- ORCID : 0000-0002-7707-6367
Petra Holmkvist
- Function : Author
- PersonId : 822426
- ORCID : 0000-0002-5324-5170
Simon Tavernier
- Function : Author
- PersonId : 795643
- ORCID : 0000-0003-2514-5655
Aaron Silva-Sanchez
- Function : Author
- PersonId : 822427
- ORCID : 0000-0002-1882-2534
Luisa Klotz
- Function : Author
- PersonId : 763004
- ORCID : 0000-0001-5439-9633
Troy Randall
- Function : Author
- PersonId : 822428
- ORCID : 0000-0003-0643-0311
Allan Mowat
- Function : Author
- PersonId : 822429
- ORCID : 0000-0001-9389-3079
Knut Kotarsky
- Function : Author
- PersonId : 803526
- ORCID : 0000-0003-3785-0327
Bernard Malissen
- Function : Author
- PersonId : 807282
- ORCID : 0000-0003-1340-9342
William Agace
- Function : Author
- PersonId : 800539
- ORCID : 0000-0003-3823-5772
Abstract
Intestinal cDC1 drive the generation of FoxP3 + CD8 + T regs to maintain tolerance to epithelial-derived self-antigen.