<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03566011</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T06:19:22+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma</title>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <surname>Jacquelot</surname>
              </persName>
              <idno type="idhal" notation="numeric">777539</idno>
              <idno type="halauthorid" notation="string">1014349-777539</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0282-1892</idno>
              <idno type="IDREF">https://www.idref.fr/194083357</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-557384"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cyril</forename>
                <surname>Seillet</surname>
              </persName>
              <idno type="idhal" notation="numeric">760085</idno>
              <idno type="halauthorid" notation="string">335389-760085</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0941-8679</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Minyu</forename>
                <surname>Wang</surname>
              </persName>
              <idno type="halauthorid">2425531-0</idno>
              <affiliation ref="#struct-130078"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Angela</forename>
                <surname>Pizzolla</surname>
              </persName>
              <idno type="idhal" notation="numeric">822441</idno>
              <idno type="halauthorid" notation="string">2425532-822441</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2024-4144</idno>
              <affiliation ref="#struct-130078"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yang</forename>
                <surname>Liao</surname>
              </persName>
              <idno type="halauthorid">717507-0</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
              <affiliation ref="#struct-575314"/>
              <affiliation ref="#struct-348003"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Soroor</forename>
                <surname>Hediyeh-Zadeh</surname>
              </persName>
              <idno type="idhal" notation="numeric">798301</idno>
              <idno type="halauthorid" notation="string">1709509-798301</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7513-6779</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sharon</forename>
                <surname>Grisaru-Tal</surname>
              </persName>
              <idno type="halauthorid">2425533-0</idno>
              <affiliation ref="#struct-63133"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cynthia</forename>
                <surname>Louis</surname>
              </persName>
              <idno type="idhal" notation="numeric">803159</idno>
              <idno type="halauthorid" notation="string">2054502-803159</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8382-6358</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Qiutong</forename>
                <surname>Huang</surname>
              </persName>
              <idno type="halauthorid">1349657-0</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
              <affiliation ref="#struct-250752"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jaring</forename>
                <surname>Schreuder</surname>
              </persName>
              <idno type="idhal" notation="numeric">822442</idno>
              <idno type="halauthorid" notation="string">2425534-822442</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7579-0006</idno>
              <affiliation ref="#struct-250752"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fernando</forename>
                <surname>Souza-Fonseca-Guimaraes</surname>
              </persName>
              <idno type="halauthorid">679967-0</idno>
              <affiliation ref="#struct-250752"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Carolyn</forename>
                <surname>de Graaf</surname>
              </persName>
              <idno type="halauthorid">2425535-0</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kevin</forename>
                <surname>Thia</surname>
              </persName>
              <idno type="halauthorid">2425536-0</idno>
              <affiliation ref="#struct-130078"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sean</forename>
                <surname>Macdonald</surname>
              </persName>
              <idno type="halauthorid">2425537-0</idno>
              <affiliation ref="#struct-130078"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mary</forename>
                <surname>Camilleri</surname>
              </persName>
              <idno type="halauthorid">1729741-0</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kylie</forename>
                <surname>Luong</surname>
              </persName>
              <idno type="idhal" notation="numeric">794584</idno>
              <idno type="halauthorid" notation="string">1556931-794584</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1459-2604</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Shengbo</forename>
                <surname>Zhang</surname>
              </persName>
              <idno type="idhal" notation="numeric">822443</idno>
              <idno type="halauthorid" notation="string">2425538-822443</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3870-0590</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>Chopin</surname>
              </persName>
              <idno type="halauthorid">1349973-0</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Tristan</forename>
                <surname>Molden-Hauer</surname>
              </persName>
              <idno type="halauthorid">2425539-0</idno>
              <affiliation ref="#struct-130078"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stephen</forename>
                <surname>Nutt</surname>
              </persName>
              <idno type="idhal" notation="numeric">798692</idno>
              <idno type="halauthorid" notation="string">1729737-798692</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0020-6637</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Viktor</forename>
                <surname>Umansky</surname>
              </persName>
              <idno type="halauthorid">1014361-0</idno>
              <affiliation ref="#struct-150185"/>
              <affiliation ref="#struct-550306"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bogoljub</forename>
                <surname>Ciric</surname>
              </persName>
              <idno type="halauthorid">2054509-0</idno>
              <affiliation ref="#struct-542448"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Joanna</forename>
                <surname>Groom</surname>
              </persName>
              <idno type="idhal" notation="numeric">798693</idno>
              <idno type="halauthorid" notation="string">1729747-798693</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5251-7835</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paul</forename>
                <surname>Foster</surname>
              </persName>
              <idno type="halauthorid">1693943-0</idno>
              <affiliation ref="#struct-302331"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philip</forename>
                <surname>Hansbro</surname>
              </persName>
              <idno type="idhal" notation="numeric">822444</idno>
              <idno type="halauthorid" notation="string">2425540-822444</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4741-3035</idno>
              <affiliation ref="#struct-302331"/>
              <affiliation ref="#struct-1040178"/>
              <affiliation ref="#struct-301138"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Andrew</forename>
                <surname>Mckenzie</surname>
              </persName>
              <idno type="idhal" notation="numeric">804107</idno>
              <idno type="halauthorid" notation="string">2088533-804107</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9757-2512</idno>
              <affiliation ref="#struct-1048555"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Daniel</forename>
                <surname>Gray</surname>
              </persName>
              <idno type="idhal" notation="numeric">804249</idno>
              <idno type="halauthorid" notation="string">2090384-804249</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8457-8242</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Andreas</forename>
                <surname>Behren</surname>
              </persName>
              <idno type="halauthorid">2425541-0</idno>
              <affiliation ref="#struct-575314"/>
              <affiliation ref="#struct-348003"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jonathan</forename>
                <surname>Cebon</surname>
              </persName>
              <idno type="halauthorid">2425542-0</idno>
              <affiliation ref="#struct-575314"/>
              <affiliation ref="#struct-348003"/>
              <affiliation ref="#struct-306322"/>
              <affiliation ref="#struct-500261"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Vivier</surname>
              </persName>
              <email type="md5">5bfb77e73d4fd86616173673fdef6ee1</email>
              <email type="domain">ciml.univ-mrs.fr</email>
              <idno type="idhal" notation="string">eric-vivier</idno>
              <idno type="idhal" notation="numeric">17342</idno>
              <idno type="halauthorid" notation="string">32004-17342</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-8939-2010</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7022-8287</idno>
              <idno type="IDREF">https://www.idref.fr/076121712</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=NlmFOgMAAAAJ</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-8939-2010</idno>
              <affiliation ref="#struct-182245"/>
              <affiliation ref="#struct-111290"/>
              <affiliation ref="#struct-300093"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ian</forename>
                <surname>Wicks</surname>
              </persName>
              <idno type="idhal" notation="numeric">803161</idno>
              <idno type="halauthorid" notation="string">2054510-803161</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7050-6822</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Joseph</forename>
                <surname>Trapani</surname>
              </persName>
              <idno type="halauthorid">2425543-0</idno>
              <affiliation ref="#struct-130078"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ariel</forename>
                <surname>Munitz</surname>
              </persName>
              <idno type="idhal" notation="numeric">800197</idno>
              <idno type="halauthorid" notation="string">1819812-800197</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1626-3019</idno>
              <affiliation ref="#struct-63133"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Melissa</forename>
                <surname>Davis</surname>
              </persName>
              <idno type="idhal" notation="numeric">803160</idno>
              <idno type="halauthorid" notation="string">2054507-803160</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4864-7033</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Wei</forename>
                <surname>Shi</surname>
              </persName>
              <idno type="halauthorid">802278-0</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-575314"/>
              <affiliation ref="#struct-348003"/>
              <affiliation ref="#struct-306322"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paul</forename>
                <surname>Neeson</surname>
              </persName>
              <idno type="idhal" notation="numeric">822445</idno>
              <idno type="halauthorid" notation="string">2425544-822445</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2729-5887</idno>
              <affiliation ref="#struct-306322"/>
              <affiliation ref="#struct-130078"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gabrielle</forename>
                <surname>Belz</surname>
              </persName>
              <idno type="idhal" notation="numeric">798691</idno>
              <idno type="halauthorid" notation="string">1729732-798691</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9660-9587</idno>
              <affiliation ref="#struct-98122"/>
              <affiliation ref="#struct-306322"/>
              <affiliation ref="#struct-250752"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Eric</forename>
                <surname>Vivier</surname>
              </persName>
              <email type="md5">6bdaf3a18751efa0b929667db50cd403</email>
              <email type="domain">univ-amu.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-12-11 16:00:03</date>
              <date type="whenModified">2026-03-13 12:50:02</date>
              <date type="whenReleased">2024-12-12 17:06:59</date>
              <date type="whenProduced">2021-07</date>
              <date type="whenEndEmbargoed">2024-12-11</date>
              <ref type="file" target="https://amu.hal.science/hal-03566011v1/document">
                <date notBefore="2024-12-11"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://amu.hal.science/hal-03566011v1/file/main.pdf" id="file-4831552-4209489">
                <date notBefore="2024-12-11"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611091"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="19887">
                <persName>
                  <forename>Eric</forename>
                  <surname>Vivier</surname>
                </persName>
                <email type="md5">6bdaf3a18751efa0b929667db50cd403</email>
                <email type="domain">univ-amu.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03566011</idno>
            <idno type="halUri">https://amu.hal.science/hal-03566011</idno>
            <idno type="halBibtex">jacquelot:hal-03566011</idno>
            <idno type="halRefHtml">&lt;i&gt;Nature Immunology&lt;/i&gt;, 2021, 22 (7), pp.851-864. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41590-021-00943-z"&gt;&amp;#x27E8;10.1038/s41590-021-00943-z&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nature Immunology, 2021, 22 (7), pp.851-864. &amp;#x27E8;10.1038/s41590-021-00943-z&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-4831552-4209489"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="CERCLE">Publications des lauréats des projets ERC financés sur le site Aix Marseille</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <surname>Jacquelot</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">777539</idno>
                  <idno type="halauthorid" notation="string">1014349-777539</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0282-1892</idno>
                  <idno type="IDREF">https://www.idref.fr/194083357</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-557384"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cyril</forename>
                    <surname>Seillet</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">760085</idno>
                  <idno type="halauthorid" notation="string">335389-760085</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0941-8679</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Minyu</forename>
                    <surname>Wang</surname>
                  </persName>
                  <idno type="halauthorid">2425531-0</idno>
                  <affiliation ref="#struct-130078"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Angela</forename>
                    <surname>Pizzolla</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">822441</idno>
                  <idno type="halauthorid" notation="string">2425532-822441</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2024-4144</idno>
                  <affiliation ref="#struct-130078"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yang</forename>
                    <surname>Liao</surname>
                  </persName>
                  <idno type="halauthorid">717507-0</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                  <affiliation ref="#struct-575314"/>
                  <affiliation ref="#struct-348003"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Soroor</forename>
                    <surname>Hediyeh-Zadeh</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">798301</idno>
                  <idno type="halauthorid" notation="string">1709509-798301</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7513-6779</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sharon</forename>
                    <surname>Grisaru-Tal</surname>
                  </persName>
                  <idno type="halauthorid">2425533-0</idno>
                  <affiliation ref="#struct-63133"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cynthia</forename>
                    <surname>Louis</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">803159</idno>
                  <idno type="halauthorid" notation="string">2054502-803159</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8382-6358</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Qiutong</forename>
                    <surname>Huang</surname>
                  </persName>
                  <idno type="halauthorid">1349657-0</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                  <affiliation ref="#struct-250752"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jaring</forename>
                    <surname>Schreuder</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">822442</idno>
                  <idno type="halauthorid" notation="string">2425534-822442</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7579-0006</idno>
                  <affiliation ref="#struct-250752"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fernando</forename>
                    <surname>Souza-Fonseca-Guimaraes</surname>
                  </persName>
                  <idno type="halauthorid">679967-0</idno>
                  <affiliation ref="#struct-250752"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Carolyn</forename>
                    <surname>de Graaf</surname>
                  </persName>
                  <idno type="halauthorid">2425535-0</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kevin</forename>
                    <surname>Thia</surname>
                  </persName>
                  <idno type="halauthorid">2425536-0</idno>
                  <affiliation ref="#struct-130078"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sean</forename>
                    <surname>Macdonald</surname>
                  </persName>
                  <idno type="halauthorid">2425537-0</idno>
                  <affiliation ref="#struct-130078"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mary</forename>
                    <surname>Camilleri</surname>
                  </persName>
                  <idno type="halauthorid">1729741-0</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kylie</forename>
                    <surname>Luong</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">794584</idno>
                  <idno type="halauthorid" notation="string">1556931-794584</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1459-2604</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Shengbo</forename>
                    <surname>Zhang</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">822443</idno>
                  <idno type="halauthorid" notation="string">2425538-822443</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3870-0590</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>Chopin</surname>
                  </persName>
                  <idno type="halauthorid">1349973-0</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Tristan</forename>
                    <surname>Molden-Hauer</surname>
                  </persName>
                  <idno type="halauthorid">2425539-0</idno>
                  <affiliation ref="#struct-130078"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stephen</forename>
                    <surname>Nutt</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">798692</idno>
                  <idno type="halauthorid" notation="string">1729737-798692</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0020-6637</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Viktor</forename>
                    <surname>Umansky</surname>
                  </persName>
                  <idno type="halauthorid">1014361-0</idno>
                  <affiliation ref="#struct-150185"/>
                  <affiliation ref="#struct-550306"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bogoljub</forename>
                    <surname>Ciric</surname>
                  </persName>
                  <idno type="halauthorid">2054509-0</idno>
                  <affiliation ref="#struct-542448"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Joanna</forename>
                    <surname>Groom</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">798693</idno>
                  <idno type="halauthorid" notation="string">1729747-798693</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5251-7835</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paul</forename>
                    <surname>Foster</surname>
                  </persName>
                  <idno type="halauthorid">1693943-0</idno>
                  <affiliation ref="#struct-302331"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philip</forename>
                    <surname>Hansbro</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">822444</idno>
                  <idno type="halauthorid" notation="string">2425540-822444</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4741-3035</idno>
                  <affiliation ref="#struct-302331"/>
                  <affiliation ref="#struct-1040178"/>
                  <affiliation ref="#struct-301138"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Andrew</forename>
                    <surname>Mckenzie</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">804107</idno>
                  <idno type="halauthorid" notation="string">2088533-804107</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9757-2512</idno>
                  <affiliation ref="#struct-1048555"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Daniel</forename>
                    <surname>Gray</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">804249</idno>
                  <idno type="halauthorid" notation="string">2090384-804249</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8457-8242</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Andreas</forename>
                    <surname>Behren</surname>
                  </persName>
                  <idno type="halauthorid">2425541-0</idno>
                  <affiliation ref="#struct-575314"/>
                  <affiliation ref="#struct-348003"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jonathan</forename>
                    <surname>Cebon</surname>
                  </persName>
                  <idno type="halauthorid">2425542-0</idno>
                  <affiliation ref="#struct-575314"/>
                  <affiliation ref="#struct-348003"/>
                  <affiliation ref="#struct-306322"/>
                  <affiliation ref="#struct-500261"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Vivier</surname>
                  </persName>
                  <email type="md5">5bfb77e73d4fd86616173673fdef6ee1</email>
                  <email type="domain">ciml.univ-mrs.fr</email>
                  <idno type="idhal" notation="string">eric-vivier</idno>
                  <idno type="idhal" notation="numeric">17342</idno>
                  <idno type="halauthorid" notation="string">32004-17342</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-8939-2010</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7022-8287</idno>
                  <idno type="IDREF">https://www.idref.fr/076121712</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=NlmFOgMAAAAJ</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-8939-2010</idno>
                  <affiliation ref="#struct-182245"/>
                  <affiliation ref="#struct-111290"/>
                  <affiliation ref="#struct-300093"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ian</forename>
                    <surname>Wicks</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">803161</idno>
                  <idno type="halauthorid" notation="string">2054510-803161</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7050-6822</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Joseph</forename>
                    <surname>Trapani</surname>
                  </persName>
                  <idno type="halauthorid">2425543-0</idno>
                  <affiliation ref="#struct-130078"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ariel</forename>
                    <surname>Munitz</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">800197</idno>
                  <idno type="halauthorid" notation="string">1819812-800197</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1626-3019</idno>
                  <affiliation ref="#struct-63133"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Melissa</forename>
                    <surname>Davis</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">803160</idno>
                  <idno type="halauthorid" notation="string">2054507-803160</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4864-7033</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Wei</forename>
                    <surname>Shi</surname>
                  </persName>
                  <idno type="halauthorid">802278-0</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-575314"/>
                  <affiliation ref="#struct-348003"/>
                  <affiliation ref="#struct-306322"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paul</forename>
                    <surname>Neeson</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">822445</idno>
                  <idno type="halauthorid" notation="string">2425544-822445</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2729-5887</idno>
                  <affiliation ref="#struct-306322"/>
                  <affiliation ref="#struct-130078"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gabrielle</forename>
                    <surname>Belz</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">798691</idno>
                  <idno type="halauthorid" notation="string">1729732-798691</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9660-9587</idno>
                  <affiliation ref="#struct-98122"/>
                  <affiliation ref="#struct-306322"/>
                  <affiliation ref="#struct-250752"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17319</idno>
                <idno type="issn">1529-2908</idno>
                <idno type="eissn">1529-2916</idno>
                <title level="j">Nature Immunology</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">22</biblScope>
                  <biblScope unit="issue">7</biblScope>
                  <biblScope unit="pp">851-864</biblScope>
                  <date type="datePub">2021-07</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41590-021-00943-z</idno>
              <idno type="pubmed">34099918</idno>
              <idno type="pubmedcentral">PMC7611091</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little about their underlying mechanisms or whether they could be clinically relevant or targeted to improve patient outcomes. Here, we found that high ILC2 infiltration in human melanoma was associated with a good clinical prognosis. ILC2s are critical producers of the cytokine granulocyte-macrophage colony-stimulating factor, which coordinates the recruitment and activation of eosinophils to enhance antitumor responses. Tumor-infiltrating ILC2s expressed programmed cell death protein-1, which limited their intratumoral accumulation, proliferation and antitumor effector functions. This inhibition could be overcome in vivo by combining interleukin-33-driven ILC2 activation with programmed cell death protein-1 blockade to significantly increase antitumor responses. Together, our results identified ILC2s as a critical immune cell type involved in melanoma immunity and revealed a potential synergistic approach to harness ILC2 function for antitumor immunotherapies.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-98122" status="VALID">
          <orgName>The Walter and Eliza Hall Institute of Medical Research</orgName>
          <orgName type="acronym">WEHI</orgName>
          <desc>
            <address>
              <addrLine>1G Royal Parade Parkville Victoria 3052</addrLine>
              <country key="AU"/>
            </address>
            <ref type="url">http://www.wehi.edu.au/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557384" status="INCOMING">
          <orgName>Princess Margaret Cancer Centre [Toronto, Canada]</orgName>
          <desc>
            <address>
              <addrLine>Toronto</addrLine>
              <country key="CA"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-306322" status="VALID">
          <idno type="ROR">https://ror.org/01ej9dk98</idno>
          <orgName>University of Melbourne</orgName>
          <desc>
            <address>
              <addrLine>Parkville VIC 3010</addrLine>
              <country key="AU"/>
            </address>
            <ref type="url">http://www.unimelb.edu.au/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-130078" status="VALID">
          <orgName>Peter MacCallum Cancer Centre</orgName>
          <desc>
            <address>
              <addrLine>Melbourne</addrLine>
              <country key="AU"/>
            </address>
            <ref type="url">https://www.petermac.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-575314" status="INCOMING">
          <orgName>Olivia Newton-John Cancer Research Institute [Heidelberg, VIC, Australia]</orgName>
          <desc>
            <address>
              <country key="AU"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-348003" status="VALID">
          <idno type="IdRef">112470491</idno>
          <idno type="ROR">https://ror.org/01rxfrp27</idno>
          <orgName>La Trobe University [Melbourne]</orgName>
          <date type="start">1967-01-01</date>
          <desc>
            <address>
              <addrLine>Plenty Road, Bundoora, Melbourne VIC 3086</addrLine>
              <country key="AU"/>
            </address>
            <ref type="url">https://www.latrobe.edu.au/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-63133" status="VALID">
          <idno type="ROR">https://ror.org/04mhzgx49</idno>
          <orgName>Tel Aviv University</orgName>
          <orgName type="acronym">TAU</orgName>
          <desc>
            <address>
              <addrLine>Tel Aviv 699780</addrLine>
              <country key="IL"/>
            </address>
            <ref type="url">https://english.tau.ac.il/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-250752" status="VALID">
          <idno type="IdRef">028327098</idno>
          <idno type="ISNI">0000000093207537</idno>
          <idno type="ROR">https://ror.org/00rqy9422</idno>
          <idno type="Wikidata">Q866012</idno>
          <orgName>The University of Queensland</orgName>
          <orgName type="acronym">UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]</orgName>
          <date type="start">1910-01-01</date>
          <desc>
            <address>
              <addrLine>Brisbane, St Lucia, QLD 4072</addrLine>
              <country key="AU"/>
            </address>
            <ref type="url">http://www.uq.edu.au/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-150185" status="VALID">
          <orgName>German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]</orgName>
          <orgName type="acronym">DKFZ</orgName>
          <desc>
            <address>
              <addrLine>German Cancer Research Center Im Neuenheimer Feld 280 D-69120 Heidelberg</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.dkfz.de/en/index.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-550306" status="VALID">
          <idno type="ISNI">0000 0001 2190 4373</idno>
          <idno type="ROR">https://ror.org/038t36y30</idno>
          <idno type="Wikidata">Q151510</idno>
          <orgName>Ruprecht-Karls Universität Heidelberg = Ruprecht-Karls University = Universität Heidelberg = Heidelberg University</orgName>
          <date type="start">1386-10-18</date>
          <desc>
            <address>
              <addrLine>P.O. Box 105760, Grabengasse 1, Heidelberg, Baden-Württemberg, 69047</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.uni-heidelberg.de</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-542448" status="VALID">
          <orgName>Jefferson (Philadelphia University + Thomas Jefferson University)</orgName>
          <date type="start">2017-07-01</date>
          <desc>
            <address>
              <addrLine>Philadelphia</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.jefferson.edu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302331" status="VALID">
          <idno type="ISNI">0000 0001 0353 9085</idno>
          <orgName>University of Newcastle [Callaghan, Australia]</orgName>
          <orgName type="acronym">UoN</orgName>
          <desc>
            <address>
              <addrLine>University Drive, Callaghan NSW 2308</addrLine>
              <country key="AU"/>
            </address>
            <ref type="url">https://www.newcastle.edu.au/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1040178" status="VALID">
          <orgName>Centenary Institute [Sidney]</orgName>
          <desc>
            <address>
              <addrLine>Sydney</addrLine>
              <country key="AU"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1052559" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301138" status="VALID">
          <idno type="ISNI">0000 0004 1936 7611</idno>
          <idno type="ROR">https://ror.org/03f0f6041</idno>
          <orgName>University of Technology Sydney</orgName>
          <orgName type="acronym">UTS</orgName>
          <date type="start">1988-01-26</date>
          <desc>
            <address>
              <addrLine>City campus15 BroadwayUltimo NSW 2007 Sydney</addrLine>
              <country key="AU"/>
            </address>
            <ref type="url">http://www.uts.edu.au/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1048555" status="VALID">
          <orgName>MRC Laboratory of Molecular Biology [Cambridge, UK]</orgName>
          <orgName type="acronym">LMB</orgName>
          <desc>
            <address>
              <addrLine>Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, Royaume-Uni</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">https://www2.mrc-lmb.cam.ac.uk/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-237843" type="direct"/>
            <relation active="#struct-300799" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-500261" status="VALID">
          <orgName>Ludwig Institute for Cancer Research</orgName>
          <desc>
            <address>
              <addrLine>9500 Gilman Drive, La Jolla, CA 92093-0653</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.ludwigcancerresearch.org/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-182245" status="VALID">
          <idno type="IdRef">150044909</idno>
          <idno type="RNSR">200017461J</idno>
          <idno type="ROR">03vyjkj45</idno>
          <orgName>Centre d'Immunologie de Marseille - Luminy</orgName>
          <orgName type="acronym">CIML</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UM 2" active="#struct-198056" type="direct"/>
            <relation name="UMR_S 1104" active="#struct-303623" type="direct"/>
            <relation name="UMR7280" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-111290" status="VALID">
          <idno type="ROR">https://ror.org/055wa9133</idno>
          <orgName>Innate Pharma</orgName>
          <desc>
            <address>
              <addrLine>117, Avenue de Luminy - BP 30191 13276 Marseille Cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.innate-pharma.com/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300093" status="VALID">
          <idno type="ISNI">0000 0001 0404 1115 </idno>
          <idno type="ROR">https://ror.org/05jrr4320</idno>
          <orgName>Hôpital de la Timone [CHU - APHM]</orgName>
          <orgName type="acronym">TIMONE</orgName>
          <date type="start">1974-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1052559" status="VALID">
          <orgName>The University of Sidney</orgName>
          <desc>
            <address>
              <country key="AU"/>
            </address>
            <ref type="url">https://www.sydney.edu.au/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-237843" status="VALID">
          <idno type="IdRef">027706338</idno>
          <idno type="ROR">https://ror.org/013meh722</idno>
          <orgName>University of Cambridge [Cambridge, UK]</orgName>
          <orgName type="acronym">CAM</orgName>
          <desc>
            <address>
              <addrLine>The Old Schools, Trinity Lane, Cambridge CB2 1TN</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.cam.ac.uk/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300799" status="VALID">
          <orgName>Medical Research Council</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>