Post-transplant cyclophosphamide in one-antigen mismatched unrelated donor transplantation versus haploidentical transplantation in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the EBMT - Aix-Marseille Université Access content directly
Journal Articles Bone Marrow Transplantation Year : 2022

Post-transplant cyclophosphamide in one-antigen mismatched unrelated donor transplantation versus haploidentical transplantation in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the EBMT

Giorgia Battipaglia
Jacques-Emmanuel Galimard
Myriam Labopin
Anna Maria Raiola
  • Function : Author
Annalisa Ruggeri
Yener Koc
  • Function : Author
Zafer Gülbas
  • Function : Author
Antonin Vitek
  • Function : Author
Simona Sica
  • Function : Author
Jose Luiz Diez-Martin
  • Function : Author
Luca Castagna
  • Function : Author
Benedetto Bruno
  • Function : Author
Montserrat Rovira
  • Function : Author
Ivan Moiseev
Massimo Martino
Giovanni Grillo
  • Function : Author
Mercedes Colorado Araujo
  • Function : Author
Claude Eric Bulabois
  • Function : Author
Stéphanie Nguyen
Gerard Socié
Mutlu Arat
Jiri Pavlu
  • Function : Author
Johanna Tischer
  • Function : Author
Hans Martin
  • Function : Author
Lucia Lopez Corral
  • Function : Author
Goda Choi
  • Function : Author
Edouard Forcade
Andrew Mcdonald
  • Function : Author
Fabrizio Pane
  • Function : Author
Ali Bazarbachi
Fabio Ciceri
Arnon Nagler
Mohamad Mohty

Abstract

Whether to choose Haploidentical (Haplo) or one-antigen mismatched unrelated donor (1Ag-MMUD) hematopoietic cell transplantation (HCT) with post-transplant cyclophosphamide (PTCy) remains an unanswered question. We compared PTCy- Haplo-HCT to PTCy-1Ag-MMUD-HCT for acute myeloid leukemia (AML) in complete remission (three groups: 1Ag-MMUD using peripheral blood (1Ag-MMUD-PB; n = 155); Haplo using bone marrow (Haplo-BM; n = 647) or peripheral blood (Haplo-PB; n = 949)). Haplo-BM and Haplo-PB had a higher non-relapse mortality (NRM) compared to 1Ag-MMUD-PB (HR 2.28, 95% CI 1.23-4.24, p < 0.01; HR 2.65, 95% CI 1.46-4.81, p < 0.01, respectively). Haplo groups experienced a lower leukemia-free survival (LFS) compared to 1Ag-MMUD-PB (Haplo-BM: HR 1.51, 95% CI 1.06-2.14, p = 0.02; Haplo-PB: 1.47, 95% CI 1.05-2.05, p = 0.02); overall survival (OS) was also lower in Haplo-HCT (Haplo-BM: HR 1.50, 95% CI 1.02-2.21, p = 0.04; Haplo-PB: HR 1.51, 95% CI 1.05-2.19, p = 0.03). No differences were observed for graft-versus-host/relapse-free survival (GRFS) and relapse incidence (RI). Haplo-BM was associated with a lower risk of grade III-IV acute graft-versus-host disease (GVHD) (HR 0.44, 95% CI 0.24-0.81; p < 0.01), while no statistical differences were observed between groups for grade II-IV aGVHD and for cGVHD. Use of PTCy in 1Ag-MMUD-HCT is a valid alternative to consider when using alternative donors. Larger analysis of 1Ag-MMUD versus Haplo-HCT are warranted.

Domains

Cancer

Dates and versions

hal-03623542 , version 1 (29-03-2022)

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Cite

Giorgia Battipaglia, Jacques-Emmanuel Galimard, Myriam Labopin, Anna Maria Raiola, Didier Blaise, et al.. Post-transplant cyclophosphamide in one-antigen mismatched unrelated donor transplantation versus haploidentical transplantation in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the EBMT. Bone Marrow Transplantation, 2022, ⟨10.1038/s41409-022-01577-x⟩. ⟨hal-03623542⟩

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