Outcomes associated with pacemaker implantation following transcatheter aortic valve replacement: A nationwide cohort study - Aix-Marseille Université Access content directly
Journal Articles Heart Rhythm Year : 2021

Outcomes associated with pacemaker implantation following transcatheter aortic valve replacement: A nationwide cohort study

Nicolas Clementy
Arnaud Bisson
Alexandre Bodin
Julien Herbert
Thibaud Lacour
  • Function : Author
Christophe Saint Etienne
  • Function : Author
Bertrand Pierre
  • Function : Author
Dominique Babuty
  • Function : Author
Laurent Fauchier

Abstract

BACKGROUND Conduction abnormalities following transcatheter aortic valve replacement (TAVR) often may require permanent pacemaker implantation (PPM). OBJECTIVE The purpose of this study was to evaluate outcomes associated with PPM after a TAVR procedure in a large, nationwide-level population. METHODS Based on the administrative hospital discharge database, the incidence of all-cause death, cardiovascular death, and hospitalization for heart failure (HF) were retrospectively collected, based on the presence or absence of PPM, in the first 30 days following all TAVRs in France from 2010 to 2019. RESULTS Among 520,662 patients hospitalized for aortic stenosis, 49,201 were treated with TAVR. A total of 29,422 patients had follow-up >= 6 months (median 1.7 years), 22% already had PPM at baseline, and 22% underwent PPM within the first 30 days post-TAVR. Adjusted hazard ratios for the combined risk of all-cause death and hospitalization for HF, during the whole follow-up, were higher in both patients with a previous PPM and in those implanted within 30 days (hazard ratio [95% confidence interval] 1.12 [1.07-1.17] and 1.11 [1.06-1.16], respectively). CONCLUSION PPM at baseline and within 30 days post-TAVR are independently associated with higher mortality and HF hospitalization during follow-up.

Dates and versions

hal-03654595 , version 1 (28-04-2022)

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Nicolas Clementy, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Thibaud Lacour, et al.. Outcomes associated with pacemaker implantation following transcatheter aortic valve replacement: A nationwide cohort study. Heart Rhythm, 2021, 18 (12), pp.2027-2032. ⟨10.1016/j.hrthm.2021.06.1175⟩. ⟨hal-03654595⟩
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