Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study - Aix-Marseille Université Access content directly
Journal Articles QJM: An International Journal of Medicine Year : 2021

Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study

D Araiza-Garaygordobil
  • Function : Author
C Montalto
  • Function : Author
P Martinez-Amezcua
  • Function : Author
A Cabello-Lopez
  • Function : Author
R Gopar-Nieto
  • Function : Author
R Alabrese
  • Function : Author
A Almaghraby
  • Function : Author
S Catoya-Villa
  • Function : Author
M Chacon-Diaz
  • Function : Author
C Kaufmann
  • Function : Author
M Corbi-Pascual
  • Function : Author
M El-Tahlawi
  • Function : Author
A Elgohari-Abdelwahab
  • Function : Author
F Guerra
  • Function : Author
M Jarakovic
  • Function : Author
E Martinez-Gomez
  • Function : Author
L Moderato
S Montero
  • Function : Author
P Morejon-Barragan
  • Function : Author
A Omar
  • Function : Author
P Jorge-Pérez
  • Function : Author
P Przybyło
  • Function : Author
E Selim
  • Function : Author
U Sinan
  • Function : Author
M Stratinaki
  • Function : Author
O Tica
  • Function : Author
M Trêpa
  • Function : Author
A Uribarri
  • Function : Author
J Uzokov
  • Function : Author
K Wilk
  • Function : Author
K Czerwińska-Jelonkiewicz
  • Function : Author
A Sionis
  • Function : Author
M Gierlotka
  • Function : Author
S Leonardi
  • Function : Author
K Krychtiuk
  • Function : Author
G Tavazzi
  • Function : Author

Abstract

Abstract Background COVID-19 has challenged the health system organization requiring a fast reorganization of diagnostic/therapeutic pathways for patients affected by time-dependent diseases such as acute coronary syndromes (ACS). Aim To describe ACS hospitalizations, management, and complication rate before and after the COVID-19 pandemic was declared. Design Ecological retrospective study. Methods: We analyzed aggregated epidemiological data of all patients > 18 years old admitted for ACS in twenty-nine hub cardiac centers from 17 Countries across 4 continents, from December 1st, 2019 to April 15th, 2020. Data from December 2018 to April 2019 were used as historical period. Results A significant overall trend for reduction in the weekly number of ACS hospitalizations was observed (20.2%; 95% confidence interval CI [1.6, 35.4] P = 0.04). The incidence rate reached a 54% reduction during the second week of April (incidence rate ratio: 0.46, 95% CI [0.36, 0.58]) and was also significant when compared to the same months in 2019 (March and April, respectively IRR: 0.56, 95%CI [0.48, 0.67]; IRR: 0.43, 95%CI [0.32, 0.58] p < 0.001). A significant increase in door-to-balloon, door-to-needle, and total ischemic time (p <0.04 for all) in STEMI patents were reported during pandemic period. Finally, the proportion of patients with mechanical complications was higher (1.98% vs. 0.98%; P = 0.006) whereas GRACE risk score was not different. Conclusions Our results confirm that COVID-19 pandemic was associated with a significant decrease in ACS hospitalizations rate, an increase in total ischemic time and a higher rate of mechanical complications on a international scale.

Dates and versions

hal-03654615 , version 1 (28-04-2022)

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Cite

D Araiza-Garaygordobil, C Montalto, P Martinez-Amezcua, A Cabello-Lopez, R Gopar-Nieto, et al.. Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study. QJM: An International Journal of Medicine, 2021, 114 (9), pp.642-647. ⟨10.1093/qjmed/hcab013⟩. ⟨hal-03654615⟩
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