Endomembrane remodeling and dynamics in Salmonella infection - Aix-Marseille Université Access content directly
Journal Articles Microbial Cell Year : 2022

Endomembrane remodeling and dynamics in Salmonella infection

Abstract

Salmonellae are bacteria that cause moderate to severe infections in humans, depending on the strain and the immune status of the infected host. These pathogens have the particularity of residing in the cells of the infected host. They are usually found in a vacuolar compartment that the bacteria shape with the help of effector proteins. Following invasion of a eukaryotic cell, the bacterial vacuole undergoes maturation characterized by changes in localization, composition and morphology. In particular, membrane tubules stretching over the microtubule cytoskeleton are formed from the bacterial vacuole. Although these tubules do not occur in all infected cells, they are functionally important and promote intracellular replication. This review focuses on the role and significance of membrane compartment remodeling observed in infected cells and the bacterial and host cell pathways involved.
Fichier principal
Vignette du fichier
mic-09-024.pdf (1.21 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03775447 , version 1 (12-09-2022)

Licence

Attribution

Identifiers

Cite

Ziyan Fang, Stéphane Méresse. Endomembrane remodeling and dynamics in Salmonella infection. Microbial Cell , 2022, 9, pp.24 - 41. ⟨10.15698/mic2022.02.769⟩. ⟨hal-03775447⟩
28 View
24 Download

Altmetric

Share

Gmail Facebook X LinkedIn More