The reuniens and rhomboid nuclei of the thalamus: A crossroads for cognition-relevant information processing?
Résumé
Over the past twenty years, the reuniens and rhomboid (ReRh) nuclei, which constitute the ventral midline thalamus, have received constantly growing attention. Since our first review article about the functional contributions of ReRh nuclei (Cassel et al., 2013), numerous (>80) important papers have extended anatomical knowledge, including at a developmental level, introduced new and very original electrophysiological insights on ReRh functions, and brought novel results on cognitive and non-cognitive implications of the ReRh. The current review will cover these recent articles, more on Re than on Rh, and their contribution will be approached according to their affiliation with work before 2013. These neuroanatomical, electrophysiological or behavioral findings appear coherent and point to the ReRh nuclei as two major components of a multistructural system supporting numerous cognitive (and noncognitive) functions. They gate the flow of information, perhaps especially from the medial prefrontal cortex to the hippocampus and back, and coordinate activity and processing across these two (and possibly other) brain regions of major cognitive relevance.
Mots clés
Ventral midline thalamus ACC
anterior cingulate cortex
adapting (neurons)
anteromedial nucleus of the thalamus
aminophosphonovalerate
2-amino-5-phosphonopentanoic acid
region CA1 of the hippocampus
region CA3 of the hippocampus
combined attention-memory
calbindin
channel rhodopsine 2
chronic mild stress
clozapine-Noxide
context pre-exposure facilitation effect
calretinin
conditioned stimulus
dopamine
diaminobenzydine
dentate gyrus
dimethyl-4-phenylpiperazinium iodide
dorsal peduncular cortex
designer receptor exclusively activated by designer drugs
entorhinal cortex
fast spiking (neurons)
forced swim test
hippocampus
hM4Di
modified human M4 muscarinic (hM4) receptor that couples with Gi protein
hM3Dq
modified human M3 muscarinic (hM3) receptor that couples with Gq protein
immediate early genes
infralimbic cortex
intralaminar nuclei of the thalamus
intraperitoneally
inter-pair interval (for paired-pulse stimulations)
lateral entorhinal cortex
local field potential
long term depression
long term potentiation
medial entorhinal cortex
mPFC
medial prefrontal cortex
medial perforant path
magnetic resonance imaging
event-related potential (ERP)
nucleus accumbens
NMDA
N-methyl-D-aspartate
postnatal day
prelimbic cortex
prefrontal cortex
perirhinal cortex
pontine reticular formation
paratenial nucleus of the thalamus
pirithiamine-induced thiamine deficiency
parvalbumin
paraventricular hypothalamic nucleus
reuniens nucleus
rapid eye movement sleep
rhomboid nucleus
resting membrane potential
RVLM/C1
rostral ventrolateral medulla/C1 (catecholaminergic neuron group)
stratum lacunosum moleculare
slow oscillations
supramammillary nucleus
sharp-wave-ripples
slow wave sleep
tetrodotoxin
unconditioned stimulus
ventro-basal nuclei of the thalamus
vHIP
ventral hippocampus
ventral midline thalamus
ventral pallidum
vSub
ventral subiculum
VTA
ventral tegmental area
vmPFC
ventromedial prefrontal cortex
xyphoid
Anatomy
Cognition
Diseases
Electrophysiology
Memory
Reuniens nucleus
Rhomboid nucleus