Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy - Aix-Marseille Université Access content directly
Journal Articles Human Brain Mapping Year : 2022

Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy

Abstract

Whole brain ionic and metabolic imaging has potential as a powerful tool for the characterization of brain diseases. We combined sodium MRI (23 Na MRI) and 1 H-MR Spectroscopic Imaging (1 H-MRSI), assessing changes within epileptogenic networks in comparison with electrophysiologically normal networks as defined by stereotactic EEG (SEEG) recordings analysis. We applied a multi-echo density adapted 3D projection reconstruction pulse sequence at 7 T (23 Na-MRI) and a 3D echo-planar spectroscopic imaging sequence at 3 T (1 H-MRSI) in 19 patients suffering from drugresistant focal epilepsy who underwent presurgical SEEG. We investigated 23 Na MRI parameters including total sodium concentration (TSC) and the sodium signal fraction associated with the short component of T 2 * decay (f), alongside the level of metabolites N-acetyl aspartate (NAA), choline compounds (Cho), and total creatine (tCr). All measures were extracted from spherical regions of interest (ROIs) centered between two adjacent SEEG electrode contacts and z-scored against the same ROI in controls. Group comparison showed a significant increase in f only in the epileptogenic zone (EZ) compared to controls and compared to patients' propagation zone (PZ) and noninvolved zone (NIZ). TSC was significantly increased in all patients' regions compared to controls. Conversely, NAA levels were significantly lower in patients compared to controls, and lower in the EZ compared to PZ and NIZ. Multiple regression analyzing the relationship between sodium and metabolites levels revealed significant relations
Fichier principal
Vignette du fichier
Azilinon-et-al-HBM-2022.pdf (1.46 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03811157 , version 1 (11-10-2022)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

Cite

Mikhael Azilinon, Julia Makhalova, Wafaa Zaaraoui, Samuel Medina Villalon, Patrick Viout, et al.. Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy. Human Brain Mapping, In press, ⟨10.1002/hbm.26102⟩. ⟨hal-03811157⟩
32 View
102 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More