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Journal Articles Biochimie Year : 2022

Structural lessons on bacterial secretins


To exchange and communicate with their surroundings, bacteria have evolved multiple active and passive mechanisms for trans-envelope transport. Among the pore-forming complexes found in the outer membrane of Gram-negative bacteria, secretins are distinctive homo-oligomeric channels dedicated to the active translocation of voluminous structures such as folded proteins, assembled fibers, virus particles or DNA. Members of the bacterial secretin family share a common cylinder-shaped structure with a gated pore-forming part inserted in the outer membrane, and a periplasmic channel connected to the inner membrane components of the corresponding nanomachine. In this mini-review, we will present what recently determined 3D structures have told us about the mechanisms of translocation through secretins of large substrates to the bacterial surface or in the extracellular milieu.
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Dates and versions

hal-03845257 , version 1 (08-12-2022)



Brice Barbat, Badreddine Douzi, Romé Voulhoux. Structural lessons on bacterial secretins. Biochimie, 2022, 205, pp.110-116. ⟨10.1016/j.biochi.2022.08.019⟩. ⟨hal-03845257⟩
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