Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis - Aix-Marseille Université Access content directly
Journal Articles Molecules Year : 2023

Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis

Sadegh Rajabi
Huda Fatima Rajani
  • Function : Author
Niloufar Mohammadkhani
  • Function : Author
Andrés Alexis Ramírez-Coronel
Mahsa Maleki
  • Function : Author
Marc Maresca
Homa Hajimehdipoor
  • Function : Author

Abstract

Metastasis is a multi-step phenomenon during cancer development leading to the propagation of cancer cells to distant organ(s). According to estimations, metastasis results in over 90% of cancer-associated death around the globe. Long non-coding RNAs (LncRNAs) are a group of regulatory RNA molecules more than 200 base pairs in length. The main regulatory activity of these molecules is the modulation of gene expression. They have been reported to affect different stages of cancer development including proliferation, apoptosis, migration, invasion, and metastasis. An increasing number of medical data reports indicate the probable function of LncRNAs in the metastatic spread of different cancers. Phytochemical compounds, as the bioactive agents of plants, show several health benefits with a variety of biological activities. Several phytochemicals have been demonstrated to target LncRNAs to defeat cancer. This review article briefly describes the metastasis steps, summarizes data on some well-established LncRNAs with a role in metastasis, and identifies the phytochemicals with an ability to suppress cancer metastasis by targeting LncRNAs.
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hal-03955598 , version 1 (25-01-2023)

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Sadegh Rajabi, Huda Fatima Rajani, Niloufar Mohammadkhani, Andrés Alexis Ramírez-Coronel, Mahsa Maleki, et al.. Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis. Molecules, 2023, 28, ⟨10.3390/molecules28030987⟩. ⟨hal-03955598⟩
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