Time to steroids impacts visual outcome of optic neuritis in MOGAD - Aix-Marseille Université Access content directly
Journal Articles Journal of Neurology, Neurosurgery and Psychiatry Year : 2023

Time to steroids impacts visual outcome of optic neuritis in MOGAD

Julie Pique
  • Function : Author
Xavier Ayrignac
  • Function : Author
Bertrand Bourre
  • Function : Author
Jonathan Ciron
Mikael Cohen
Nicolas Collongues
Romain Deschamps
Elisabeth Maillart
  • Function : Author
Alexis Montcuquet
  • Function : Author
Caroline Papeix
Aurelie Ruet
  • Function : Author
Sandrine Wiertlewski
  • Function : Author
Helene Zephir
  • Function : Author
Romain Marignier
  • Function : Author

Abstract

Background To characterise the response to treatment of inaugural optic neuritis (ON) in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods We searched the French MOGAD database for adults with inaugural ON with a detailed report of acute treatment modalities and measures of high-contrast best-corrected visual acuity (BCVA) at nadir and after 3 months. Predictors of visual outcomes were assessed by multivariable analysis. Results Among 245 patients with at least one episode of ON, 82 fulfilled all criteria, and data on the peripapillary retinal nerve fibre layer (pRNFL) were available for 44. All patients received methylprednisolone (MP), combined with plasma exchange in 18. After 3 months, 75 of 82 (91%) patients retained full BCVA recovery, and median (range) pRNFL of the affected eye was 72 µm (40–102). Failure to regain 0.0 logarithmic minimum angle of resolution vision (Snellen 20/20) at 3 months was associated with time to first MP treatment ≥10 days (OR 16, 95% CI 1.14 to 213, p=0.01). pRNFL thickness after 3 months was related to better BCVA at nadir and time to first MP treatment <10 days (r2=19%, p=0.004 and r2=11%, p=0.03, respectively). Conclusions Time to MP affects functional but also structural visual outcomes of ON in MOGAD.
No file

Dates and versions

hal-03963560 , version 1 (30-01-2023)

Identifiers

Cite

Julie Rode, Julie Pique, Adil Maarouf, Xavier Ayrignac, Bertrand Bourre, et al.. Time to steroids impacts visual outcome of optic neuritis in MOGAD. Journal of Neurology, Neurosurgery and Psychiatry, 2023, jnnp-2022-330360. ⟨10.1136/jnnp-2022-330360⟩. ⟨hal-03963560⟩
19 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More