Controlled Synthesis of Small Water-Soluble Hybrid Gold Nanoparticles: An Optimized Strategy for Stable Nano-Dispersion and Towards Cellular Uptake - Aix-Marseille Université Access content directly
Journal Articles Frontiers in Mechanical Engineering Year : 2022

Controlled Synthesis of Small Water-Soluble Hybrid Gold Nanoparticles: An Optimized Strategy for Stable Nano-Dispersion and Towards Cellular Uptake

Tracy Bouyon Yenda
  • Function : Author
Imene Khichane
  • Function : Author
Quentin Gobert
  • Function : Author
Rathinasabapathi Prabhakaran
  • Function : Author
Alexandre de Nonneville
  • Function : Author
Thierry Djenizian
  • Function : Author
Sébastien Salas
  • Function : Author
Frédéric Dallemer
  • Function : Author

Abstract

The development of effective drug delivery systems is one of the major challenges in the fight against cancer. Gold nanoparticles could effectively harness cancer therapies by improving their potency while reducing toxic side effects. In this work, we describe a high-yield one-step synthesis of small water-soluble gold nanoparticles (AuNPs). Efficient purification was monitored, and discrete structure was fully characterized by combining molecular analytical technics (UV-visible and NMR spectroscopies) and solid-state analyses (thermal gravimetric analysis and transmission electron microscopy). These AuNPs have good dispersibility in various biocompatible media and can be used without any additives. Preliminary study with in vitro treatment of IB115 human cancer cells showed massive cellular uptake associated to moderate intrinsic cytotoxicity. The high control of the synthesis and the small size of these AuNPs are offering fine surface properties control, crucial for challenging biological nano-dispersion issues. Thus, limitation of the agglomeration of nanoparticles and improvement of interaction with the surface of cell should open new leads for vectorization of drugs or imaging probes for diagnosis.

Dates and versions

hal-03982276 , version 1 (10-02-2023)

Identifiers

Cite

Tracy Bouyon Yenda, Carine Jiguet-Jiglaire, Imene Khichane, Quentin Gobert, Rathinasabapathi Prabhakaran, et al.. Controlled Synthesis of Small Water-Soluble Hybrid Gold Nanoparticles: An Optimized Strategy for Stable Nano-Dispersion and Towards Cellular Uptake. Frontiers in Mechanical Engineering, 2022, 8, ⟨10.3389/fmech.2022.824837⟩. ⟨hal-03982276⟩
15 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More