Detection of distant metastases and distant second primary cancers in head and neck squamous cell carcinoma: comparison of [18F]FDG PET/MRI and [18F]FDG PET/CT - Aix-Marseille Université Access content directly
Journal Articles Insights into Imaging Year : 2022

Detection of distant metastases and distant second primary cancers in head and neck squamous cell carcinoma: comparison of [18F]FDG PET/MRI and [18F]FDG PET/CT

Eirini Katirtzidou
  • Function : Author
Olivier Rager
  • Function : Author
Antoine Poncet
  • Function : Author
Vincent Lenoir
  • Function : Author
Nicolas Dulguerov
  • Function : Author
Alexandra Platon
  • Function : Author
Valentina Garibotto
  • Function : Author
Habib Zaidi
  • Function : Author
Minerva Becker

Abstract

Purpose This prospective study aimed to compare the diagnostic performance of [ 18 ]FDG PET/MRI and PET/CT for the detection of distant metastases and distant second primary cancers in patients with head and neck squamous cell carcinoma (HNSCC). Methods A total of 103 [ 18 F]FDG PET/MRI examinations immediately followed by PET/CT were obtained in 82 consecutive patients for staging of primary HNSCC ( n = 38), suspected loco-regional recurrence/follow-up ( n = 41) or unknown primary HNSCC ( n = 3). Histology and follow-up > 2 years formed the standard of reference. Blinded readers evaluated the anonymized PET/MRI and PET/CT examinations separately using a 5-point Likert score. Statistical analysis included: receiver operating characteristic (ROC) analysis, jackknife alternative free-response ROC (JAFROC) and region-of-interest (ROI)-based ROC to account for data clustering and sensitivity/specificity/accuracy comparisons for a score ≥ 3. Results Distant metastases and distant second primary cancers were present in 23/103 (22%) examinations in 16/82 (19.5%) patients, and they were more common in the post-treatment group (11/41, 27%) than in the primary HNSCC group (3/38, 8%), p = 0.039. The area under the curve (AUC) per patient/examination/lesion was 0.947 [0.927–1]/0.965 [0.917–1]/0.957 [0.928–0.987] for PET/MRI and 0.975 [0.950–1]/0.968 [0.920–1]/0.944 [0.910–0.979] for PET/CT, respectively ( p > 0.05). The diagnostic performance of PET/MRI and PET/CT was similar according to JAFROC ( p = 0.919) and ROI-based ROC analysis ( p = 0.574). Sensitivity/specificity/accuracy for PET/MRI and PET/CT for a score ≥ 3 was 94%/88%/89% and 94%/91%/91% per patient, 96%/90%/91% and 96%/93%/93% per examination and 95%/85%/90% and 90%/86%/88% per lesion, respectively, p > 0.05. Conclusions In HNSCC patients, PET/MRI and PET/CT had a high and similar diagnostic performance for detecting distant metastases and distant second primary cancers.
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hal-04009123 , version 1 (17-07-2023)

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Eirini Katirtzidou, Olivier Rager, Arthur Damien Varoquaux, Antoine Poncet, Vincent Lenoir, et al.. Detection of distant metastases and distant second primary cancers in head and neck squamous cell carcinoma: comparison of [18F]FDG PET/MRI and [18F]FDG PET/CT. Insights into Imaging, 2022, 13 (1), pp.121. ⟨10.1186/s13244-022-01261-0⟩. ⟨hal-04009123⟩
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