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          <titleStmt>
            <title xml:lang="en">A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer</title>
            <author role="aut">
              <persName>
                <forename type="first">Chang</forename>
                <surname>Gong</surname>
              </persName>
              <idno type="halauthorid">2192554-0</idno>
              <affiliation ref="#struct-59542"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ziliang</forename>
                <surname>Cheng</surname>
              </persName>
              <idno type="halauthorid">2800063-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yaping</forename>
                <surname>Yang</surname>
              </persName>
              <idno type="halauthorid">984937-0</idno>
              <affiliation ref="#struct-85453"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jun</forename>
                <surname>Shen</surname>
              </persName>
              <idno type="halauthorid">585747-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yingying</forename>
                <surname>Zhu</surname>
              </persName>
              <idno type="halauthorid">1246411-0</idno>
              <affiliation ref="#struct-1004777"/>
              <affiliation ref="#struct-505936"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Li</forename>
                <surname>Ling</surname>
              </persName>
              <idno type="halauthorid">2800064-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Wanyi</forename>
                <surname>Lin</surname>
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              <idno type="halauthorid">2800065-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Zhigang</forename>
                <surname>Yu</surname>
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              <idno type="halauthorid">2800066-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Zhihua</forename>
                <surname>Li</surname>
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              <affiliation ref="#struct-440556"/>
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            <author role="aut">
              <persName>
                <forename type="first">Weige</forename>
                <surname>Tan</surname>
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              <idno type="halauthorid">2800067-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Chushan</forename>
                <surname>Zheng</surname>
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            <author role="aut">
              <persName>
                <forename type="first">Wenbo</forename>
                <surname>Zheng</surname>
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            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jiajie</forename>
                <surname>Zhong</surname>
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            <author role="aut">
              <persName>
                <forename type="first">Xiang</forename>
                <surname>Zhang</surname>
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              <idno type="halauthorid">801303-0</idno>
              <affiliation ref="#struct-351709"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yunjie</forename>
                <surname>Zeng</surname>
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            <author role="aut">
              <persName>
                <forename type="first">Qiang</forename>
                <surname>Liu</surname>
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                <forename type="first">R. Stephanie</forename>
                <surname>Huang</surname>
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            <author role="aut">
              <persName>
                <forename type="first">Andrzej L.</forename>
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            <author role="aut">
              <persName>
                <forename type="first">Eddy S.</forename>
                <surname>Yang</surname>
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            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Bertucci</surname>
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                <forename type="first">Francesco</forename>
                <surname>Ricci</surname>
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              <affiliation ref="#struct-301888"/>
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                <forename type="first">Armando</forename>
                <surname>Orlandi</surname>
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            <author role="aut">
              <persName>
                <forename type="first">Mona P.</forename>
                <surname>Tan</surname>
              </persName>
              <idno type="halauthorid">2800077-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mathew A.</forename>
                <surname>Cherian</surname>
              </persName>
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            </author>
            <author role="aut">
              <persName>
                <forename type="first">Erwei</forename>
                <surname>Song</surname>
              </persName>
              <idno type="halauthorid">1103745-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>yves</forename>
                <surname>collette</surname>
              </persName>
              <email type="md5">159f9fadb68000fe135a73051af8a850</email>
              <email type="domain">inserm.fr</email>
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              <date type="whenSubmitted">2023-04-28 17:00:24</date>
              <date type="whenModified">2025-07-03 17:06:04</date>
              <date type="whenReleased">2023-04-28 17:00:24</date>
              <date type="whenProduced">2022</date>
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            <idno type="halRefHtml">&lt;i&gt;Science China Life Sciences&lt;/i&gt;, 2022, 65 (11), pp.2205-2217. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s11427-022-2104-3"&gt;&amp;#x27E8;10.1007/s11427-022-2104-3&amp;#x27E9;&lt;/a&gt;</idno>
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            <idno type="stamp" n="EPHE">École Pratique des Hautes Études</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="CURIE" corresp="INSERM">Institut Curie</idno>
            <idno type="stamp" n="PAOLI_CALMETTES" corresp="FNCLCC">Institut Paoli-Calmettes</idno>
            <idno type="stamp" n="CORDELIERS" corresp="SORBONNE-UNIVERSITE">Centre de recherche des Cordeliers</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
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            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="CRCM">Centre de Recherche en Cancérologie de Marseille</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="TEST-DEV">TEST-DEV</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
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                <title xml:lang="en">A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Chang</forename>
                    <surname>Gong</surname>
                  </persName>
                  <idno type="halauthorid">2192554-0</idno>
                  <affiliation ref="#struct-59542"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ziliang</forename>
                    <surname>Cheng</surname>
                  </persName>
                  <idno type="halauthorid">2800063-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yaping</forename>
                    <surname>Yang</surname>
                  </persName>
                  <idno type="halauthorid">984937-0</idno>
                  <affiliation ref="#struct-85453"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jun</forename>
                    <surname>Shen</surname>
                  </persName>
                  <idno type="halauthorid">585747-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yingying</forename>
                    <surname>Zhu</surname>
                  </persName>
                  <idno type="halauthorid">1246411-0</idno>
                  <affiliation ref="#struct-1004777"/>
                  <affiliation ref="#struct-505936"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Li</forename>
                    <surname>Ling</surname>
                  </persName>
                  <idno type="halauthorid">2800064-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Wanyi</forename>
                    <surname>Lin</surname>
                  </persName>
                  <idno type="halauthorid">2800065-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Zhigang</forename>
                    <surname>Yu</surname>
                  </persName>
                  <idno type="halauthorid">2800066-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Zhihua</forename>
                    <surname>Li</surname>
                  </persName>
                  <idno type="halauthorid">1218237-0</idno>
                  <affiliation ref="#struct-440556"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Weige</forename>
                    <surname>Tan</surname>
                  </persName>
                  <idno type="halauthorid">2800067-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Chushan</forename>
                    <surname>Zheng</surname>
                  </persName>
                  <idno type="halauthorid">2800068-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Wenbo</forename>
                    <surname>Zheng</surname>
                  </persName>
                  <idno type="halauthorid">2800069-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jiajie</forename>
                    <surname>Zhong</surname>
                  </persName>
                  <idno type="halauthorid">2800070-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xiang</forename>
                    <surname>Zhang</surname>
                  </persName>
                  <idno type="halauthorid">801303-0</idno>
                  <affiliation ref="#struct-351709"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yunjie</forename>
                    <surname>Zeng</surname>
                  </persName>
                  <idno type="halauthorid">2800071-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Qiang</forename>
                    <surname>Liu</surname>
                  </persName>
                  <idno type="halauthorid">658265-0</idno>
                  <affiliation ref="#struct-121172"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">R. Stephanie</forename>
                    <surname>Huang</surname>
                  </persName>
                  <idno type="halauthorid">2800072-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Andrzej L.</forename>
                    <surname>Komorowski</surname>
                  </persName>
                  <idno type="halauthorid">2800073-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eddy S.</forename>
                    <surname>Yang</surname>
                  </persName>
                  <idno type="halauthorid">2800074-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Bertucci</surname>
                  </persName>
                  <email type="md5">a9198c738177d1ce607a59826ab2edc8</email>
                  <email type="domain">ipc.unicancer.fr</email>
                  <idno type="idhal" notation="string">francois-bertucci</idno>
                  <idno type="idhal" notation="numeric">753650</idno>
                  <idno type="halauthorid" notation="string">40186-753650</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0157-0959</idno>
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                <author role="aut">
                  <persName>
                    <forename type="first">Francesco</forename>
                    <surname>Ricci</surname>
                  </persName>
                  <idno type="halauthorid">42504-0</idno>
                  <affiliation ref="#struct-301888"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Armando</forename>
                    <surname>Orlandi</surname>
                  </persName>
                  <idno type="halauthorid">2463831-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gianluca</forename>
                    <surname>Franceschini</surname>
                  </persName>
                  <idno type="halauthorid">2208540-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kazuaki</forename>
                    <surname>Takabe</surname>
                  </persName>
                  <idno type="halauthorid">2800075-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Suzanne</forename>
                    <surname>Klimberg</surname>
                  </persName>
                  <idno type="halauthorid">2140552-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Naohiro</forename>
                    <surname>Ishii</surname>
                  </persName>
                  <idno type="halauthorid">2800076-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Angela</forename>
                    <surname>Toss</surname>
                  </persName>
                  <idno type="halauthorid">1628662-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mona P.</forename>
                    <surname>Tan</surname>
                  </persName>
                  <idno type="halauthorid">2800077-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mathew A.</forename>
                    <surname>Cherian</surname>
                  </persName>
                  <idno type="halauthorid">2800078-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Erwei</forename>
                    <surname>Song</surname>
                  </persName>
                  <idno type="halauthorid">1103745-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">109366</idno>
                <idno type="issn">1674-7305</idno>
                <idno type="eissn">1869-1889</idno>
                <title level="j">Science China Life Sciences</title>
                <imprint>
                  <publisher>Springer</publisher>
                  <biblScope unit="volume">65</biblScope>
                  <biblScope unit="issue">11</biblScope>
                  <biblScope unit="pp">2205-2217</biblScope>
                  <date type="datePub">2022</date>
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              <idno type="doi">10.1007/s11427-022-2104-3</idno>
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              <language ident="en">English</language>
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              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
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            <abstract xml:lang="en">
              <p>Patients with hormone receptor (HR)-positive tumors breast cancer usually experience a relatively low pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). Here, we derived a 10-microRNA risk score (10-miRNA RS)-based model with better performance in the prediction of pCR and validated its relation with the disease-free survival (DFS) in 755 HR-positive breast cancer patients (273, 265, and 217 in the training, internal, and external validation sets, respectively). This model, presented as a nomogram, included four parameters: the 10-miRNA RS found in our previous study, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) status, and volume transfer constant (K-trans). Favorable calibration and discrimination of 10-miRNA RS-based model with areas under the curve (AUC) of 0.865, 0.811, and 0.804 were shown in the training, internal, and external validation sets, respectively. Patients who have higher nomogram score (&gt;92.2) with NAC treatment would have longer DFS (hazard ratio=0.57; 95%CI: 0.39-0.83; P=0.004). In summary, our data showed the 10-miRNA RS-based model could precisely identify more patients who can attain pCR to NAC, which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HR-positive breast cancer.</p>
            </abstract>
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