Over its four years of operation, Academy-3 has fostered the emergence of innovative interdisciplinary research in the five main axes. Thirty-two major projects were supported. About 28% of the projects address critical questions on relationships between anthropogenic activities and human health, 19% focus on hazards related to our Région Sud, 15% target seismic hazards approached in a generic manner, 16% address broad-scale questions of our Universe, and, finally, 22% of projects explore innovative approaches or instruments to best observe humans, the Earth or Space and to better cope with the intricate hazards that threaten them. Altogether, the 32 projects involve about 200 UCA scientists and 100 students at various levels, including more than 30 PhD students. The projects have also attracted 10 young post-doctoral researchers from abroad. More than 80% of the projects have built new collaborations within UCA and abroad, and almost 60% of them have brought together 3 or more UCA laboratories or institutes in original collaborations. They are thus clearly transdisciplinary and “structuring”. A quarter of the projects funded by Academy-3 have even brought together physical and social sciences, thereby paving the way towards a more complete hazard assessment.his booklet is organized in five chapters corresponding to the five axes of Academy-3, namely: Environment and health hazards; Natural and anthropogenic hazards in the Euro-Mediterranean region; Physics of large earthquakes and related hazards; Origin and physics of our Universe and of our Earth; Instrumentation and methodologies for Earth and Space observation and hazard and resilience assessment. For each project, a short summary of the project is presented together with its participants, budget, possible developments and actions for future work, and links for more information on the project. An individual comment is also provided to emphasize why Academy-3 chose to support each project. In reading the brief description of these projects, we hope that you will find opportunities for new research ideas and collaborations, and even more, cause for optimism in the challenges that our planet and its inhabitants are facing.