Understanding enhancer function to understand human disease - Aix-Marseille Université Accéder directement au contenu
Autre Publication Scientifique BioEssays Année : 2023

Understanding enhancer function to understand human disease

Résumé

In multicellular organisms, spatial and temporal regulation of gene expression is crucial for development, cellular differentiation, and homeostasis. Cell-type-specific regulation of gene expression is achieved through the interaction between regulatory elements that are either proximal (promoters) or distal (enhancers, silencers, insulators) to gene transcription start sites (TSSs). Enhancers, which primarily function in a cell type-specific manner, are short (100-1000 bp) DNA
Fichier principal
Vignette du fichier
Spicuglia_Bioeesays_Editorial_final.pdf (178.68 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04288514 , version 1 (16-11-2023)

Identifiants

Citer

Salvatore Spicuglia, Alvaro Rada-Iglesias. Understanding enhancer function to understand human disease. 2023, ⟨10.1002/bies.202300149⟩. ⟨hal-04288514⟩

Collections

UNIV-AMU
21 Consultations
10 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More