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Article Dans Une Revue Respirology Année : 2024

Chronic interstitial lung disease associated with systemic lupus erythematosus: A multicentric study of 89 cases

1 PHERE (UMR_S_1152 / U1152) - Physiopathologie et Epidémiologie des Maladies Respiratoires
2 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
3 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
4 INSERM UMR1152, Service de Pneumologie et Transplantation Pulmomaire
5 CRI (UMR_S_1149 / ERL_8252 / U1149) - Centre de recherche sur l'Inflammation
6 Hôpital Cochin [AP-HP]
7 ECaMO - [CRESS - U1153 / UMR_A 1125] - Clinical Epidemiology Applied to Osteoarticular Diseases | Épidémiologie clinique appliquée aux maladies rhumatismales et musculo-squelettiques
8 CeRAINO - Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France
9 Hôpital Avicenne [AP-HP]
10 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
11 GRC 4 - Theranoscan - Groupe de recherche clinique Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules
12 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
13 HPPIT - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
14 Service de Pneumologie [AP-HP, Hôpital Bicêtre]
15 MEPHI - Microbes évolution phylogénie et infections
16 Service de Pneumologie, Centre de compétences des maladies pulmonaires rares, CHU Nord, AP-HM, Marseille
17 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
18 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
19 IVPC - Infections Virales et Pathologie Comparée - UMR 754
Martine Rémi-Jardin
  • Fonction : Auteur

Résumé

Abstract Background and Objective Chronic interstitial lung disease (ILD) occurs rarely with systemic lupus erythematosus (SLE) as compared with other connective tissue diseases. This multicentric retrospective study of patients with SLE‐ILD from the OrphaLung and French SLE networks during 2005–2020 aimed to describe the characteristics of patients with SLE‐ILD and analyse factors associated with prognosis. Methods We analysed data for 89 patients with SLE‐ILD (82 women, 92.1%) (median age at SLE diagnosis: 35 years [interquartile range 27–47]). All patients met the 2019 EULAR/ACR criteria for the diagnosis of SLE. Results Forty two (47.2%) patients were positive for anti‐ribonuclear protein antibodies and 45 (50.6%) for anti SSA/Ro antibodies. A total of 58 (65.2%) patients had another connective tissue disease: Sjögren's syndrome ( n = 33, 37.1%), systemic sclerosis ( n = 14, 15.7%), inflammatory myopathy ( n = 6, 6.7%), or rheumatoid arthritis ( n = 6, 6.7%). ILD was diagnosed along with SLE in 25 (28.1%) patients and at a median of 6 (0–14) years after the SLE diagnosis. The most frequent CT pattern was suggestive of non‐specific interstitial pneumonia ( n = 41, 46.0%) with or without superimposed organizing pneumonia. After a median follow‐up of 86.5 [39.5–161.2] months, 18 (20.2%) patients had died and 6 (6.7%) underwent lung transplantation. The median 5‐year and 10‐year transplantation‐free survival were 96% (92–100) and 87% (78–97). In total, 44 (49.4%) patients showed ILD progression. Cutaneous manifestations and Raynaud's phenomenon were associated with better survival. Only forced vital capacity was significantly associated with survival and ILD progression. Conclusion ILD is a rare manifestation of SLE with good overall prognosis but with possible risk of ILD progression. Patients with SLE‐ILD frequently have another connective tissue disease.

Dates et versions

hal-04543777 , version 1 (12-04-2024)

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Lou Deneuville, Arthur Mageau, Marie Pierre Debray, Karim Sacre, Nathalie Costedoat-Chalumeau, et al.. Chronic interstitial lung disease associated with systemic lupus erythematosus: A multicentric study of 89 cases. Respirology, 2024, ⟨10.1111/resp.14703⟩. ⟨hal-04543777⟩
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