Visual function resists early neurodegeneration in the visual system in primary progressive multiple sclerosis - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Journal of Neurology, Neurosurgery and Psychiatry Année : 2023

Visual function resists early neurodegeneration in the visual system in primary progressive multiple sclerosis

Sina Rosenkranz
Lilija Gutmann
  • Fonction : Auteur
Arzu Ceylan Has Silemek
  • Fonction : Auteur
Michael Dorr
Vivien Häußler
Margareta Lüpke
  • Fonction : Auteur
Andrea Mönch
  • Fonction : Auteur
Stefanie Reinhardt
  • Fonction : Auteur
Jens Kuhle
  • Fonction : Auteur
Penelope Tilsley
  • Fonction : Auteur
Christoph Heesen
Manuel Friese
Alexander Brandt
  • Fonction : Auteur
Friedemann Paul
  • Fonction : Auteur
Hanna Zimmermann
  • Fonction : Auteur

Résumé

Neurodegeneration in multiple sclerosis (MS) affects the visual system but dynamics and pathomechanisms over several years especially in primary progressive MS (PPMS) are not fully understood. Methods We assessed longitudinal changes in visual function, retinal neurodegeneration using optical coherence tomography, MRI and serum NfL (sNfL) levels in a prospective PPMS cohort and matched healthy controls. We investigated the changes over time, correlations between outcomes and with loss of visual function. Results We followed 81 patients with PPMS (mean disease duration 5.9 years) over 2.7 years on average. Retinal nerve fibre layer thickness (RNFL) was reduced in comparison with controls (90.1 vs 97.8 µm; p<0.001). Visual function quantified by the area under the log contrast sensitivity function (AULCSF) remained stable over a continuous loss of RNFL (0.46 µm/year, 95% CI 0.10 to 0.82; p=0.015) up until a mean turning point of 91 µm from which the AULCSF deteriorated. Intereye RNFL asymmetry above 6 µm, suggestive of subclinical optic neuritis, occurred in 15 patients and was related to lower AULCSF but occurred also in 5 out of 44 controls. Patients with an AULCSF progression had a faster increase in Expanded Disability Status Scale (beta=0.17/year, p=0.043). sNfL levels were elevated in patients (12.2 pg/mL vs 8.0 pg/mL, p<0.001), but remained stable during follow-up (beta=–0.14 pg/mL/year, p=0.291) and were not associated with other outcomes. Conclusion Whereas neurodegeneration in the anterior visual system is already present at onset, visual function is not impaired until a certain turning point. sNfL is not correlated with structural or functional impairment in the visual system.
Fichier principal
Vignette du fichier
VisualSystemInPPMS_manuscript_revision_230418_arxiv.pdf (914.71 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04555246 , version 1 (22-04-2024)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Sina Rosenkranz, Lilija Gutmann, Arzu Ceylan Has Silemek, Michael Dorr, Vivien Häußler, et al.. Visual function resists early neurodegeneration in the visual system in primary progressive multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 2023, 94 (11), pp.924-933. ⟨10.1136/jnnp-2023-331183⟩. ⟨hal-04555246⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More