Synthesis of acyclic analogues of adenosine sulfonamides and their activity against RNA cap guanine N 7-methyltransferase of SARS-CoV-2
Abstract
N-Arylsulfonamide-based adenosine analogues were previously shown to be potent inhibitors of SARS-CoV-2 RNA cap guanine N7-methyltransferase nsp14. Here, we synthesized three series of N-arylsulfonamide acyclic analogues of adenosine as bisubstrates of nsp14. Most of these acyclic compounds were barely active at 50 μM against this cap N7-methyltransferase.
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