Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development
Résumé
Lack of Trem2 in mice impairs hippocampal neuronal bioenergetics during development d CA1 but not CA3 neurons show reduced mitochondrial mass and metabolism d CA1 metabolic dysfunction is later accompanied by synaptic and network alterations d A partial reduction in Trem2 is sufficient to alter neuronal metabolic fitness
Domaines
Sciences du Vivant [q-bio]
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Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development.pdf (10.72 Mo)
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