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authFullName_s : Micael Hardy

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds (vol 14C, pg 316, 2017)

Balaraman Kalyanaraman , Gang Chen , Micael Hardy , Olivier Ouari , Marcos Lopez , et al.
Redox Biology, 2018, 16, pp.426--427. ⟨10.1016/j.redox.2018.03.001⟩
Journal articles hal-02091900v1

Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases

Jacek Zielonka , Micael Hardy , Radoslaw Michalski , Adam Sikora , Monika Zielonka , et al.
Cell Biochemistry and Biophysics, 2017, 75 (3-4), pp.335--349. ⟨10.1007/s12013-017-0813-6⟩
Journal articles hal-01774183v1

Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies

Balaraman Kalyanaraman , Gang Cheng , Micael Hardy , Olivier Ouari , Adam Sikora , et al.
Cell Biochemistry and Biophysics, 2017, 75 (3-4), pp.311--317. ⟨10.1007/s12013-017-0796-3⟩
Journal articles hal-01774204v1

Design of New Derivatives of Nitrone DEPMPO Functionalized at C-4 for Further Specific Applications in Superoxide Radical Detection

Florence Chalier , Micael Hardy , Olivier Ouari , Antal Rockenbauer , Paul Tordo
Journal of Organic Chemistry, 2007, 72 (21), pp.7886 - 7892. ⟨10.1021/jo071070s⟩
Journal articles istex hal-01792588v1

Synthesis and Spin-Trapping Properties of a Trifluoromethyl Analogue of DMPO: 5-Methyl-5-trifluoromethyl-1-pyrroline N-Oxide (5-TFDMPO)

Hakim Karoui , Celine Nsanzumuhire , François Le Moigne , Micael Hardy , Didier Siri , et al.
Chemistry - A European Journal, 2014, 20 (14), pp.4064-4071. ⟨10.1002/chem.201303774⟩
Journal articles istex hal-01397895v1

Mitochondria-Targeted Spin Traps: Synthesis, Superoxide Spin Trapping, and Mitochondrial Uptake

Micael Hardy , Florent Poulhés , Egon Rizzato , Antal Rockenbauer , Karol Banaszak , et al.
Chemical Research in Toxicology, 2014, 27 (7), pp.1155 - 1165. ⟨10.1021/tx500032e⟩
Journal articles hal-01414126v1

Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism

Gang Cheng , Jacek Zielonka , Donna Mcallister , Micael Hardy , Olivier Ouari , et al.
Cancer Letters, 2015, 365 (1), pp.96 - 106. ⟨10.1016/j.canlet.2015.05.016⟩
Journal articles hal-01414616v1
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Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects

Gang Cheng , Micael Hardy , Paytsar Topchyan , Ryan Zander , Peter Volberding , et al.
Journal articles hal-03627839v1

Spin trapping

Jacek Zielonka , Micael Hardy , B. Kalyanaraman
Spin trapping, 13, royal society of chemistry, pp.482-518, 2021
Book sections hal-03627665v1
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Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation

Gang Cheng , Micael Hardy , Ming You , Balaraman Kalyanaraman
Scientific Reports, 2022, 12 (1), pp.5143. ⟨10.1038/s41598-022-08984-6⟩
Journal articles hal-04114888v1

Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals

Eric Besson , Stéphane Gastaldi , Emily Bloch , Jacek Zielonka , Monika Zielonka , et al.
Analyst, 2019, 144 (14), pp.4194-4203. ⟨10.1039/c9an00468h⟩
Journal articles hal-02187288v1

Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators.

Gang Cheng , Jacek Zielonka , Micael Hardy , Olivier Ouari , Christopher R. Chitambar , et al.
Oncotarget, 2019, 10 (37), pp.3518--3532. ⟨10.18632/oncotarget.26943⟩
Journal articles hal-02491548v1

HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes — The ultimate approach for intra- and extracellular superoxide detection

Balaraman Kalyanaraman , Brian P. Dranka , Micael Hardy , Radoslaw Michalski , Jacek Zielonka
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (2), pp.739 - 744. ⟨10.1016/j.bbagen.2013.05.008⟩
Journal articles hal-01414361v1

Boronate Probes as Diagnostic Tools for Real Time Monitoring of Peroxynitrite and Hydroperoxides

Jacek Zielonka , Adam Sikora , Micael Hardy , Joy Joseph , Brian P. Dranka , et al.
Chemical Research in Toxicology, 2012, 25 (9), pp.1793 - 1799. ⟨10.1021/tx300164j⟩
Journal articles hal-01425058v1
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Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide

Radosław Michalski , David Thiebaut , Bartosz Michałowski , Mehmet M Ayhan , Micael Hardy , et al.
Scientific Reports, 2020, 10, ⟨10.1038/s41598-020-75373-2⟩
Journal articles hal-03244541v1

Mito-honokiol compounds and methods of synthesis and use thereof

B. Kalyanaraman , Jacek Zielonka , Gang Cheng , Micael Hardy , Olivier Ouari , et al.
United States, Patent n° : US 20210070787 A1 20210311. 2021
Patents hal-03627816v1
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Detection of superoxide production in stimulated and unstimulated living cells using new cyclic nitrone spin traps

Kahina Abbas , Micael Hardy , Florent Poulhès , Hakim Karoui , Paul Tordo , et al.
Free Radical Biology and Medicine, 2014, 71, pp.281 - 290. ⟨10.1016/j.freeradbiomed.2014.03.019⟩
Journal articles hal-01414138v1

Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms

Balaraman Kalyanaraman , Gang Cheng , Micael Hardy , Olivier Ouari , Adam Sikora , et al.
Interface Focus, 2017, 7 (2), pp.20160109. ⟨10.1098/rsfs.2016.0109⟩
Journal articles hal-01774201v1
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Polyphenolic Boronates Inhibit Tumor Cell Proliferation: Potential Mitigators of Oxidants in the Tumor Microenvironment

Gang Cheng , Hakim Karoui , Micael Hardy , Balaraman Kalyanaraman
Cancers, 2023, 15 (4), pp.1089. ⟨10.3390/cancers15041089⟩
Journal articles hal-04114827v1

Homolysis/mesolysis of alkoxyamines activated by chemical oxidation and photochemical-triggered radical reactions at room temperature

Gérard Audran , Mitchell Blyth , Michelle Coote , Georg Gescheidt , Micael Hardy , et al.
Organic Chemistry Frontiers, 2021, 8 (23), pp.6561-6576. ⟨10.1039/d1qo01276b⟩
Journal articles hal-04115158v1
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Chemoprevention of Lung Cancer with a Combination of Mitochondria-Targeted Compounds

Qi Zhang , Donghai Xiong , Jing Pan , Yian Wang , Micael Hardy , et al.
Cancers, 2022, 14 (10), pp.2538. ⟨10.3390/cancers14102538⟩
Journal articles hal-04114988v1

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

Gang Cheng , Jacek Zielonka , Olivier Ouari , Marcos Lopez , Donna Mcallister , et al.
Cancer Research, 2016, 76 (13), pp.3904--3915. ⟨10.1158/0008-5472.CAN-15-2534⟩
Journal articles hal-01460665v1

Metabolic stability of superoxide adducts derived from newly developed cyclic nitrone spin traps

Nicolas Bézière , Micael Hardy , Florent Poulhès , Hakim Karoui , Paul Tordo , et al.
Free Radical Biology and Medicine, 2014, 67, pp.150 - 158. ⟨10.1016/j.freeradbiomed.2013.10.812⟩
Journal articles hal-01414178v1

High-Throughput Screening of NOX Inhibitors.

Jacek Zielonka , Monika Zielonka , Gang Cheng , Micael Hardy , Balaraman Kalyanaraman
Methods in Molecular Biology, 2019, 1982, pp.429--446. ⟨10.1007/978-1-4939-9424-3_25⟩
Journal articles hal-02491524v1

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis

Gang Cheng , Qi Zhang , Jing Pan , Yongik Lee , Olivier Ouari , et al.
Nature Communications, 2019, 10, pp.2205. ⟨10.1038/s41467-019-10042-1⟩
Journal articles hal-02491552v1

Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products

Micael Hardy , Jacek Zielonka , Hakim Karoui , Adam Sikora , Radoslaw Michalski , et al.
Antioxidants & redox signaling, 2018, ⟨10.1089/ars.2017.7398⟩
Journal articles hal-02091844v1
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EPR Investigations to Study the Impact of Mito-Metformin on the Mitochondrial Function of Prostate Cancer Cells

Donatienne D’hose , Barbara Mathieu , Lionel Mignion , Micael Hardy , Olivier Ouari , et al.
Molecules, 2022, 27 (18), pp.5872. ⟨10.3390/molecules27185872⟩
Journal articles hal-04114863v1
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Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities

Balaraman Kalyanaraman , Gang Cheng , Micael Hardy
Frontiers in Oncology, 2022, 12, pp.816504. ⟨10.3389/fonc.2022.816504⟩
Journal articles hal-04114941v1

Hydropropidine: A novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide

Radoslaw Michalski , Jacek Zielonka , Micael Hardy , Joy Joseph , Balaraman Kalyanaraman
Free Radical Biology and Medicine, 2012, 54, pp.135 - 147. ⟨10.1016/j.freeradbiomed.2012.09.018⟩
Journal articles hal-01425080v1

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Jacek Zielonka , Joy Joseph , Adam Sikora , Micael Hardy , Olivier Ouari , et al.
Chemical Reviews, 2017, 117 (15), pp.10043--10120. ⟨10.1021/acs.chemrev.7b00042⟩
Journal articles hal-01774202v1