Olive Oil and Vitamin D Synergistically Prevent Bone Loss in Mice - Aix-Marseille Université Access content directly
Journal Articles PLoS ONE Year : 2014

Olive Oil and Vitamin D Synergistically Prevent Bone Loss in Mice

Abstract

As the Mediterranean diet (and particularly olive oil) has been associated with bone health, we investigated the impact of extra virgin oil as a source of polyphenols on bone metabolism. In that purpose sham-operated (SH) or ovariectomized (OVX) mice were subjected to refined or virgin olive oil. Two supplementary OVX groups were given either refined or virgin olive oil fortified with vitamin D3, to assess the possible synergistic effects with another liposoluble nutrient. After 30 days of exposure, bone mineral density and gene expression were evaluated. Consistent with previous data, ovariectomy was associated with increased bone turnover and led to impaired bone mass and micro-architecture. The expression of oxidative stress markers were enhanced as well. Virgin olive oil fortified with vitamin D3 prevented such changes in terms of both bone remodeling and bone mineral density. The expression of inflammation and oxidative stress mRNA was also lower in this group. Overall, our data suggest a protective impact of virgin olive oil as a source of polyphenols in addition to vitamin D3 on bone metabolism through improvement of oxidative stress and inflammation.
Fichier principal
Vignette du fichier
fetchObject.pdf (1.57 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-01238769 , version 1 (07-12-2015)

Identifiers

Cite

Camille Tagliaferri, Marie-Jeanne Davicco, Patrice Lebecque, Stéphane Georgé, Marie-Jo Amiot, et al.. Olive Oil and Vitamin D Synergistically Prevent Bone Loss in Mice. PLoS ONE, 2014, 9 (e115817), e115817 (19 p.). ⟨10.1371/journal.pone.0115817⟩. ⟨hal-01238769⟩
158 View
143 Download

Altmetric

Share

Gmail Facebook X LinkedIn More