Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria - Aix-Marseille Université Access content directly
Journal Articles FEBS Letters Year : 2011

Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria

Abstract

In Gram-negative bacteria, the envelope is a sophisticated barrier protecting the cell against external toxic compounds. Membrane transporters, e.g., porins or efflux pumps, are main filters regulating the internal accumulation of various hydrophilic molecules. Regarding bacterial susceptibility towards antibacterial agents, membrane permeability is part of the early bacterial defense. The bacterium manages the translocation process, influx and efflux, to control the intracellular concentration of various molecules. Antibiotics and biocides are substrates of these mechanisms and the continuing emergence of multidrug resistant isolates is a growing worldwide health concern. Different strategies could be proposed to bypass the bacterial membrane barrier, comprising influx and efflux mechanisms, in order to restore the activity of antibiotics against resistant bacteria.
Fichier principal
Vignette du fichier
FEBS Lett2011(585).pdf (851.75 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01425039 , version 1 (16-01-2017)

Identifiers

Cite

Jean-Michel Bolla, Sandrine Alibert-Franco, Jadwiga Handzlik, Jacqueline Chevalier, Abdallah Mahamoud, et al.. Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria. FEBS Letters, 2011, 585 (11), pp.1682-1690. ⟨10.1016/j.febslet.2011.04.054⟩. ⟨hal-01425039⟩
103 View
522 Download

Altmetric

Share

Gmail Facebook X LinkedIn More