Erythropoietin Pretreatment of Transplanted Endothelial Colony-Forming Cells Enhances Recovery in a Cerebral Ischemia Model by Increasing Their Homing Ability: A SPECT/CT Study - Aix-Marseille Université Access content directly
Journal Articles Journal of Nuclear Medicine Year : 2016

Erythropoietin Pretreatment of Transplanted Endothelial Colony-Forming Cells Enhances Recovery in a Cerebral Ischemia Model by Increasing Their Homing Ability: A SPECT/CT Study

Youssef Bennis
Jimmy Stalin
Lionel Velly

Abstract

Endothelial colony-forming cells (ECFCs) are promising candidates for cell therapy of ischemic diseases, as less than 10% of patients with an ischemic stroke are eligible for thrombolysis. We previously reported that erythropoietin priming of ECFCs increased their in vitro and in vivo angiogenic properties in mice with hindlimb ischemia. The present study used SPECT/CT to evaluate whether priming of ECFCs with erythropoietin could enhance their homing to the ischemic site after transient middle cerebral artery occlusion (MCAO) followed by reperfusion in rats and potentiate their protective or regenerative effect on blood-brain barrier (BBB) disruption, cerebral apoptosis, and cerebral blood flow (CBF).

Dates and versions

hal-01451166 , version 1 (31-01-2017)

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Philippe Garrigue, Guillaume Hache, Youssef Bennis, Pauline Brige, Jimmy Stalin, et al.. Erythropoietin Pretreatment of Transplanted Endothelial Colony-Forming Cells Enhances Recovery in a Cerebral Ischemia Model by Increasing Their Homing Ability: A SPECT/CT Study. Journal of Nuclear Medicine, 2016, 57 (11), pp.1798-1804. ⟨10.2967/jnumed.115.170308⟩. ⟨hal-01451166⟩
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